Results 71 to 80 of about 267,722 (305)

Age estimation using DNA methylation technique in forensics: a systematic review

Egyptian Journal of Forensic Sciences, 2020
Background In addition to the DNA sequence, epigenetic markers have become substantial forensic tools during the last decade. Estimating the age of an individual from human biological remains may provide information for a forensic investigation.
Chaerita Maulani, Elza Ibrahim Auerkari
doaj   +1 more source

Methylation age acceleration does not predict mortality in schizophrenia. [PDF]

, 2019
Schizophrenia (SCZ) is associated with high mortality. DNA methylation levels vary over the life course, and pre-selected combinations of methylation array probes can be used to estimate "methylation age" (mAge). mAge correlates highly with chronological
Burrage, Joe, Hannon, Eilis, Kowalec, Kaarina, Mansell, Georgina, Mill, Jonathan, Ophoff, Roel A, Ori, Anil PS, Sullivan, Patrick F   +7 more
core   +1 more source

DNA methylation-based age clocks: From age prediction to age reversion

Ageing Research Reviews, 2021
Aging as an irretrievable occurrence throughout the entire life is characterized by a progressive decline in physiological functionality and enhanced disease vulnerability. Numerous studies have demonstrated that epigenetic modifications, particularly DNA methylation (DNAm), correlate with aging and age-related diseases.
Rezvan Noroozi, Soudeh Ghafouri-Fard, Aleksandra Pisarek, Joanna Rudnicka, Magdalena Spólnicka, Wojciech Branicki, Mohammad Taheri, Ewelina Pośpiech   +7 more
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Interrelationships and determinants of aging biomarkers in cord blood

Journal of Translational Medicine, 2022
Background Increasing evidence supports the concept of prenatal programming as an early factor in the aging process. DNA methylation age (DNAm age), global genome-wide DNA methylation (global methylation), telomere length (TL), and mitochondrial DNA ...
Brigitte Reimann, Dries S. Martens, Congrong Wang, Akram Ghantous, Zdenko Herceg, Michelle Plusquin, Tim S. Nawrot   +6 more
doaj   +1 more source

Application of a novel molecular method to age free-living wild Bechstein's bats [PDF]

, 2018
The age profile of populations fundamentally affects their conservation status. Yet, age is frequently difficult to assess in wild animals. Here, we assessed the use of DNA methylation of homologous genes to establish the age structure of a rare and ...
Altschul, Batulevicius, Bekaert, Botsford, Briggs, Brunet-Rossini, Chakrabarti, Cheng, Christensen, Cunningham, De Paz, Dennis, Dietz, Dunshea, Fleischer, Gaisler, Goel, Grönniger, Hannum, Horvath, Jones, Jung, Kerth, Koch, Kunz, Llamas, Maegawa, Mallet, Mizroch, Munshi-South, Nelson, Oli, Olsen, Olsen, Petkovich, Polanowski, Puechmaille, R Core Team, Richardson, RStudio, Sand, Speed, Storz, Stubbs, Tella, Teschendorff, Thompson, Tost, Turbill, Weidner, Wilkinson, Zbieć-Piekarska   +51 more
core   +3 more sources

DNA Methylation Markers to Assess Biological Age [PDF]

, 2019
Among the different biomarkers of aging based on omics and clinical data, DNA methylation clocks stand apart providing unmatched accuracy in assessing the biological age of both humans and animal models of aging. Here, we discuss robustness of DNA methylation clocks and bounds on their out-of-sample performance and review computational strategies for ...
Podolskiy, Dmitriy I., Gladyshev, Vadim N.   +1 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age

Epigenetics & Chromatin
Background DNA methylation plays a crucial role in gene regulation and epigenetic inheritance across diverse organisms. Daphnia magna, a model organism in ecological and evolutionary research, has been widely used to study environmental responses ...
Ruoshui Liu, Marco Morselli, Lev Y. Yampolsky, Leonid Peshkin, Matteo Pellegrini   +4 more
doaj   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source