Results 61 to 70 of about 267,722 (305)

DNA methylation and cognitive aging

Oncotarget, 2015
With ever-increasing elder population, the high incidence of age-related diseases such as neurodegenerative disorders has turned out to be a huge public concern. Especially the elders and their families dreadfully suffer from the learning, behavioral and cognitive impairments.
openaire   +4 more sources

Age-associated DNA methylation in pediatric populations [PDF]

Genome Research, 2012
DNA methylation (DNAm) plays diverse roles in human biology, but this dynamic epigenetic mark remains far from fully characterized. Although earlier studies uncovered loci that undergo age-associated DNAm changes in adults, little is known about such changes during childhood. Despite profound DNAm plasticity during embryogenesis, monozygotic twins show
Reid S, Alisch, Benjamin G, Barwick, Pankaj, Chopra, Leila K, Myrick, Glen A, Satten, Karen N, Conneely, Stephen T, Warren   +6 more
openaire   +2 more sources

Role of Age-Related Changes in DNA Methylation in the Disproportionate Susceptibility and Worse Outcomes of Sepsis in Older Adults

Frontiers in Medicine, 2022
Sepsis, a complex multisystem disorder, is among the top causes of hospitalization and mortality in older adults. However, the mechanisms underlying the disproportionate susceptibility to sepsis and worse outcomes in the elderly are not well understood ...
Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Lingling Shen, Lingling Shen, Lingling Shen, Lingling Shen, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Yang Chen, Yang Chen, Yang Chen, Yang Chen, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Qun Su, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Francesco Neri, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +41 more
doaj   +1 more source

Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing [PDF]

, 2011
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal
Beltran, L, Berney, DM, Brentnall, AR, Cuzick, J, Kim, DC, Kudahetti, SC, Lorincz, AT, Lu, YJ, Mao, XY, Shaw, GL, Thorat, MA, Vasiljevic, N, Wu, KQ, Xue, LY, Yu, YW   +14 more
core   +2 more sources

Dietary intervention modifies DNA methylation age assessed by the epigenetic clock [PDF]

, 2018
Scope: Alterations in DNA methylation patterns are correlated with aging, environmental exposures and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum.
Aryee, Barres, Baylin, Breton, Byun, Byun, Castro, Celis-Morales, Chen, Fang, Fodinger, Friso, Hannum, Hobbs, Horvath, Horvath, Horvath, Issa, Jung, Kok, Liew, Luczak, Maegawa, Magalhães, Mandaviya, Marioni, Marioni, Mathers, Mathers, Milenkovic, Milenkovic, Perna, Pirouzpanah, Piyathilake, Quach, Robertson, Russo, Teschendorff, Winkels, Zannas, Zhong   +40 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Age-associated DNA methylation changes in Xenopus frogs

Epigenetics, 2023
Age-associated changes in DNA methylation have been characterized across various animals, but not yet in amphibians, which are of particular interest because they include widely studied model organisms.
Marco Morselli, Ronan Bennett, Nikko-Ideen Shaidani, Marko Horb, Leonid Peshkin, Matteo Pellegrini   +5 more
doaj   +1 more source

24-Hour Rhythms of DNA Methylation and Their Relation with Rhythms of RNA Expression in the Human Dorsolateral Prefrontal Cortex [PDF]

, 2014
Circadian rhythms modulate the biology of many human tissues, including brain tissues, and are driven by a near 24-hour transcriptional feedback loop. These rhythms are paralleled by 24-hour rhythms of large portions of the transcriptome.
Bennett, David A., Buchman, Aron S., Chibnik, Lori B., De Jager, Philip L., Lim, Andrew S. P., Myers, Amanda J., Schneider, Julie A., Srivastava, Gyan P., Xu, Jishu, Yu, Lei   +9 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants

Frontiers in Endocrinology, 2016
BackgroundPreterm birth associates with a substantially increased risk of later cardiovascular disease and neurodevelopmental disorders. Understanding underlying mechanisms will facilitate the development of screening and intervention strategies to ...
Chinthika Piyasena, Chinthika Piyasena, Jessy Cartier, Nadine Provençal, Tobias Wiechmann, Batbayar Khulan, Raju Sunderesan, Gopi Menon, Jonathan R. Seckl, Rebecca M. Reynolds, Elisabeth B. Binder, Amanda J. Drake   +11 more
doaj   +1 more source