British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Is there a role for impaired DNA mismatch repair system in the pathogenesis of ameloblastomas? A scoping review. [PDF]
J Oral Biol Craniofac ResMartins-de-Barros AV +7 more
europepmc +1 more source
Biotechnology and Bioengineering, EarlyView.Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) – Cas9‐based genome editing has emerged as a widely used tool across various disciplines, ranging from molecular biology to gene therapy. This revolutionary technology, which enables precise gene editing, represents a significant advancement in biotechnology, opening new frontiers for ...
Ali Mertcan Köse +3 more
wiley +1 more source
DNA mismatch repair mediated by Mlh1-Pms1 endonuclease-catalyzed mispair excision. [PDF]
Proc Natl Acad Sci U S APalacio T +5 more
europepmc +1 more source
Dysfunctional DNA Mismatch Repair Drives the Evolution of Gene Amplification in MTX-Resistant Human Colorectal Cancer Cells. [PDF]
Int J Mol SciWang X +7 more
europepmc +1 more source
Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy
BMEMat, EarlyView.This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang +5 more
wiley +1 more source
Analysis of DNA mismatch repair and microsatellite instability in molecular typing of endometrial carcinoma. [PDF]
Discov OncolLi NM, Cheng HP, Zhou P, Li XH.
europepmc +1 more source
Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia
BMEMat, EarlyView.CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai +14 more
wiley +1 more source
Loss of DNA mismatch repair genes leads to acquisition of antibiotic resistance independent of secondary mutations. [PDF]
PLoS GenetBautista DE +4 more
europepmc +1 more source
Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife
Biological Reviews, EarlyView.ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief +4 more
wiley +1 more source