Results 151 to 160 of about 297,565 (330)

Multi‐Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend

Advanced Science, EarlyView.
The 2500‐year‐old Mulberry‐dyke and Fish‐pond agricultural heritage system reveals how interconnected habitats foster microbial diversity. Multi‐habitat landscapes enhance microbial diversity through cross‐habitat dispersal and adaptive trait convergence. Globally, regions with diverse habitats support a greater diversity of soil microbiomes.
Jintao He, Jian Xiao, Xiaoqiang Shen, Kankan Zhao, Xiaoyu Lei, Huarui Zhang, Chao Sun, Huijie Lu, Yongqi Shao   +8 more
wiley   +1 more source

A Comparative Study of Methyl-BEAMing and Droplet Digital PCR for MGMT Gene Promoter Hypermethylation Detection

Diagnostics
Background: O-6-methylguanine-DNA methyltransferase is responsible for the direct repair of O6-methylguanine lesions induced by alkylating agents, including temozolomide.
Marco Macagno, Valeria Pessei, Noemi Congiusta, Luca Lazzari, Sara Erika Bellomo, Fariha Idrees, Alessandro Cavaliere, Filippo Pietrantonio, Alessandra Raimondi, Eleonora Gusmaroli, Maria Giulia Zampino, Lorenzo Gervaso, Davide Ciardiello, Giuseppe Mondello, Armando Santoro, Nicola Personeni, Emanuela Bonoldi, Maria Costanza Aquilano, Emanuele Valtorta, Salvatore Siena, Andrea Sartore-Bianchi, Alessio Amatu, Erica Francesca Bonazzina, Katia Bruna Bencardino, Guido Serini, Silvia Marsoni, Ludovic Barault, Federica Di Nicolantonio, Federica Maione   +28 more
doaj   +1 more source

Data from Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer

, 2023
Robert A. Edwards, Mavee Witherspoon, Kehui Wang, Kambiz Afrasiabi, Trang Pham, Lutz Birnbaumer, Steven M. Lipkin   +6 more
openalex   +1 more source

Comprehensive Analysis of Differentially Expressed Long Non-Coding RNA-mRNA in the Adenoma–Carcinoma Sequence of DNA Mismatch Repair Proficient Colon Cancer [PDF]

, 2020
Wenkun Li, Qian Li, Jiang Ge, Yun Wang, Nanshan Li, Yueqiong Lao, Yadan Wang, Kuiliang Liu, Chunmei Guo, Wu Lin, Guojun Jiang, Nan Wei, Canghai Wang, Hong Liu, Jing Wu   +14 more
openalex   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells [PDF]

, 2016
Thomas W van Ravesteyn, Marleen Dekker, Alexander Fish, Titia K. Sixma, Astrid Wolters, Rob J. Dekker, Hein P. J. te Riele   +6 more
openalex   +1 more source

Impact of DNA mismatch repair proteins deficiency on number and ratio of lymph nodal metastases in colorectal adenocarcinoma

, 2023
Federica Zannier, Valentina Angerilli, Gaya Spolverato, Stefano Brignola, Daniele Sandonà, Mariangela Balistreri, Marianna Sabbadin, Sara Lonardi, Francesca Bergamo, Claudia Mescoli, Marco Scarpa, Quoc Riccardo Bao, Angelo Paolo Dei Tos, Salvatore Pucciarelli, Emanuele L.D. Urso, Matteo Fassan   +15 more
openalex   +2 more sources

Mechanisms and functions of DNA mismatch repair

Cell Research, 2008
Guo-Min Li
semanticscholar   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Cancer risk in mutation carriers of DNA‐mismatch‐repair genes

International Journal of Cancer, 1999
M. Aarnio, R. Sankila, E. Pukkala, R. Salovaara, L. Aaltonen, A. de la Chapelle, P. Peltomäki, J. Mecklin, H. Järvinen   +8 more
semanticscholar   +1 more source