Results 11 to 20 of about 71,628 (244)

Downregulation of both mismatch repair and non-homologous end-joining pathways in hypoxic brain tumour cell lines [PDF]

PeerJ, 2021
Glioblastoma, a grade IV astrocytoma, has a poor survival rate in part due to ineffective treatment options available. These tumours are heterogeneous with areas of low oxygen levels, termed hypoxic regions.
Sophie Cowman, Barry Pizer, Violaine Sée   +2 more
doaj   +2 more sources

Error-free and error-prone DNA repair gene expression data through reprogramming and passage in human iPS cells

Data in Brief, 2020
We recently found that DNA repair-related gene expression could be altered by reprogramming as well as the increased expression of genes that accurately convey genomic information, such as homologous recombination (HR) and mismatch repair (MMR), and the ...
Yasuhide Yoshimura, Daisuke Okuzaki
doaj   +1 more source

An Msh3 ATPase domain mutation has no effect on MMR function

BMC Research Notes, 2017
Objective To demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model. Results The DNA mismatch repair proteins are members of the ABC family of ATPases.
Yasmin Edwards
doaj   +1 more source

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Cell Reports, 2017
Summary: DNA interstrand crosslinks (ICLs) that are repaired in non-dividing cells must be recognized independently of replication-associated DNA unwinding. Using cell-free extracts from Xenopus eggs that support neither replication nor transcription, we
Niyo Kato, Yoshitaka Kawasoe, Hannah Williams, Elena Coates, Upasana Roy, Yuqian Shi, Lorena S. Beese, Orlando D. Schärer, Hong Yan, Max E. Gottesman, Tatsuro S. Takahashi, Jean Gautier   +11 more
doaj   +1 more source

Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin

BMC Cancer, 2010
Background One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin.
Smith Jennifer M, Stubbert Lawton J, McKay Bruce C   +2 more
doaj   +1 more source

Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. [PDF]

PLoS ONE, 2012
Different studies have suggested that mutation rate varies at different positions in the genome. In this work we analyzed if the chromosomal context and/or the presence of GATC sites can affect the frameshift mutation rate in the Escherichia coli genome.
Mariana A Martina, Elisa M E Correa, Carlos E Argaraña, José L Barra   +3 more
doaj   +1 more source

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae

Nature Communications, 2021
Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap ...
Felipe A. Calil, Bin-Zhong Li, Kendall A. Torres, Katarina Nguyen, Nikki Bowen, Christopher D. Putnam, Richard D. Kolodner   +6 more
doaj   +1 more source

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.

PLoS Genetics, 2015
During replication, mismatch repair proteins recognize and repair mispaired bases that escape the proofreading activity of DNA polymerase. In this work, we tested the model that the eukaryotic mismatch recognition complex tracks with the advancing ...
Joanna E Haye, Alison E Gammie
doaj   +1 more source

Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site

Genes and Environment, 2018
Background A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DNA repair mechanism elaborately, an
Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki, Isao Kuraoka   +3 more
doaj   +1 more source

High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

eLife, 2017
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Yi Yin, Margaret Dominska, Eunice Yim, Thomas D Petes   +3 more
doaj   +1 more source