Results 201 to 210 of about 70,351 (245)

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Clinicopathological Significance of Defective DNA Mismatch Repair in Endometrial Carcinoma: A Single-Center Study From Bahrain. [PDF]

Cureus
Hammad M, Almahari SAI, Umakanth S, Toorani ZA.   +3 more
europepmc   +1 more source

Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer. [PDF]

Cell Rep Med
Nowak M, Jabbar F, Rodewald AK, Gneo L, Tomasevic T, Harkin A, Iveson T, Saunders M, Kerr R, Oein K, Maka N, Hay J, Edwards J, Tomlinson I, Sansom O, Kelly C, Pezzella F, Kerr D, Easton A, Domingo E, TransSCOT group, Koelzer VH, Church DN.   +22 more
europepmc   +1 more source

Co-reactivity pattern of glucose metabolism and blood perfusion revealing DNA mismatch repair deficiency based on PET/DCE-MRI in endometrial cancer. [PDF]

Cancer Imaging
Li X, Cui B, Wang S, Gao M, Xing Q, Liu H, Lu J.   +6 more
europepmc   +1 more source

MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations. [PDF]

J Biol Chem
Kadyrova LY, Mieczkowski PA, Kadyrov FA.
europepmc   +1 more source

CDK-independent role of D-type cyclins in regulating DNA mismatch repair. [PDF]

Mol Cell
Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M.   +23 more
europepmc   +1 more source

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Eukaryotic DNA mismatch repair

Current Opinion in Genetics & Development, 1999
Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2-MSH3 and MSH2-MSH6. These two complexes have different mispair recognition properties and different abilities to support MMR. Alternative models have been proposed for how these MSH complexes function in MMR.
R D, Kolodner, G T, Marsischky
openaire   +2 more sources

Mammalian DNA Mismatch Repair

Annual Review of Genetics, 1999
▪ Abstract  DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer, S M, Deschênes, S M, Baker, R M, Liskay   +3 more
openaire   +2 more sources

Prokaryotic DNA Mismatch Repair

2006
Publisher Summary There are several scientific reviews available that deal with the multitude of molecular processes involved in repairing various DNA lesions. The chapter discusses prokaryotic DNA mismatch repair pathway. Repair of base mismatches in Escherichia coli and related bacteria is performed by two molecular yet overlapping processes: the ...
Joseph, Nimesh, Duppatlaa, Viswanadham, Rao, Desirazu N   +2 more
openaire   +2 more sources