Annals of Clinical and Translational Neurology, EarlyView.Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie +4 more
wiley +1 more source
Hydrolysis of DNA by Ce(IV)/EDTA complexes--The mechanism of DNA cleavage and design of artificial restriction enzymes-- [PDF]
, 2000 Yumi Yamamoto +3 more
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Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi +7 more
wiley +1 more source
Restriction enzymes increase efficiencies of illegitimate DNA integration but decrease homologous integration in mammalian cells [PDF]
, 2001 P. Manivasakam
openalex +1 more source
Arthritis Care &Research, EarlyView.Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur +5 more
wiley +1 more source
Restriction Enzyme BsoBI–DNA Complex [PDF]
, 2001 Mark J. van der Woerd +3 more
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Preventive Effect of Metformin in Radiation‐Induced Xerostomia
Advanced Biology, EarlyView.Head and neck cancer patients who received radiotherapy complain of severe dry mouth due to damage to the salivary glands. Metformin is an antidiabetic drug, but its radio‐protective effect has been reported. It is confirmed that metformin protects the salivary glands from radiation and provides evidence for the use of metformin in cancer treatment in ...
Sungryeal Kim +5 more
wiley +1 more source
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence [PDF]
, 2002 S. Gražulis
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Light‐Triggered Protease‐Mediated Release of Actin‐Bound Cargo from Synthetic Cells
Advanced Biology, EarlyView.TEV Prtoease‐mediated Releasable Actin‐binding Protein (TRAP) is a protein‐based platform consisting of a cargo tightly bound to reconstituted actin networks in synthetic cells which can be proteolyticly released from the bound actin, followed by its secretion through membrane translocation mediated by a cell‐penetrating peptide.
Mousumi Akter +3 more
wiley +1 more source
How the Bfi I restriction enzyme uses one active site to cut two DNA strands [PDF]
, 2003 Giedrius Sasnauskas +2 more
openalex +1 more source