Results 181 to 190 of about 2,295,017 (227)

DNA supercoiling: A regulatory signal for the λ repressor

Proceedings of the National Academy of Sciences of the United States of America, 2014
Carlo Manzo, Fenfei Leng, David Dunlap
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Supercoiling-Induced DNA Bending

Biochemistry, 2004
Local DNA bending is a critical factor for numerous DNA functions including recognition of DNA by sequence-specific regulatory binding proteins. Negative DNA supercoiling increases both local and global DNA dynamics, and this dynamic flexibility can facilitate the formation of DNA-protein complexes. We have recently shown that apexes of supercoiled DNA
Jeffrey W, Pavlicek, Elena A, Oussatcheva, Richard R, Sinden, Vladimir N, Potaman, Otto F, Sankey, Yuri L, Lyubchenko   +5 more
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Dynamics of DNA Supercoils

Science, 2012
Watching Supercoiled DNA The DNA double helix can undergo additional twisting, or supercoiling, that plays a role in transciption and protein binding, in part by bringing distant DNA locations together.
M. T. J. van Loenhout, M. V. de Grunt, C. Dekker   +2 more
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Transcription and DNA supercoiling

Current Opinion in Genetics & Development, 1993
Transcription and supercoiling of the DNA template are interrelated. This review summarizes recent progress in the study of how template topology affects transcription, and how transcription affects template topology inside wild-type and DNA topoisomerase mutant cells.
J C, Wang, A S, Lynch
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DNA supercoiling in apoptotic chromatin [PDF]

Biochemical and Biophysical Research Communications, 2003
In a previous paper, we have reported that in rat thymocyte apoptosis chromatin undergoes a specific structural change as well as an appreciable increase in the unacetylated forms of histones H3 and H4. Here, we show that H3 and H4 deacetylation bears no relation to chromatin condensation, and present new ultrastructural and topological observations ...
D'Arrigo C, Barboro P, Mormino M, Coradeghini R, Parodi S, Patrone E, Balbi C   +6 more
openaire   +3 more sources

DNA supercoiling

2005
Abstract In the first chapter, we described the classical double-helical structure of DNA, and the local alterations of that structure that can occur as a consequence of specific nucleotide sequences. We hope you now have a good feel for these concepts, and we will move on to the main subject of this book, the supercoiling of DNA, a ...
Andrew D Bates, Anthony Maxwell
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Statistical mechanics of supercoiled DNA

Physical Review E, 1995
The conformation of long supercoiled DNA loops under near physiological conditions has been the subject of a long series of laboratory and Monte Carlo experiments, and impressive agreement between theory and experiment has been achieved [1–2]. A closed unnicked DNA loop has fixed linking number: this constraint leads to a competition between twisting ...
, Marko, , Siggia
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Supercoiled DNA: Hydrodynamic model

Journal of Theoretical Biology, 1974
Two and three parameter theories have been introduced to describe the sedimentation behavior of the twisted DNA molecule compared to nontwisted DNA molecule. In the first model, the sedimentation equations have been developed using two parameters, namely, the excluded volume and the chain stiffness.
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Computer simulation of DNA supercoiling

Journal of Molecular Biology, 1991
We treat supercoiled DNA within a wormlike model with excluded volume. A modified Monte Carlo approach has been used, which allowed computer statistical-mechanical simulations of moderately and highly supercoiled DNA molecules. Even highly supercoiled molecules do not have a regular shape, though with an increase in writhing the chains look more and ...
K V, Klenin, A V, Vologodskii, V V, Anshelevich, A M, Dykhne, M D, Frank-Kamenetskii   +4 more
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Supercoil-Accelerated DNA Threading Intercalation

Biochemistry, 2009
The effect of DNA supercoiling on a sterically very demanding threading intercalation process is investigated here. We find that the threading rate of a dimeric ruthenium complex into a negatively supercoiled plasmid at low binding density is 2 orders of magnitude higher than into the cleaved linear form.
Pär, Nordell, Erik T, Jansson, Per, Lincoln   +2 more
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