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Fluctuations and Supercoiling of DNA
Science, 1994Frequently, DNA in vivo is organized into loops that are partially underwound and consequently form interwound helical supercoils. Methods from polymer statistical mechanics are used to show how the competition between entropy (thermal fluctuations) and elastic energy determines supercoil radius and pitch, in good agreement with recent experiments and ...
J F, Marko, E D, Siggia
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Supercoiling transitions of closed DNA
Physical Review E, 1994Conformations of closed DNA molecules are considered within a simple elastic model. The interplay of elastic energies of bending and twisting can lead to supercoiling induced by variations of the linking difference. These shape transformations are studied in the limit of a large length to thickness ratio of the molecule.
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Local Supercoil-Stabilized DNA Structure
Critical Reviews in Biochemistry and Molecular Biology, 1991The DNA double helix exhibits local sequence-dependent polymorphism at the level of the single base pair and dinucleotide step. Curvature of the DNA molecule occurs in DNA regions with a specific type of nucleotide sequence periodicities. Negative supercoiling induces in vitro local nucleotide sequence-dependent DNA structures such as cruciforms, left ...
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PICH and TOP3A cooperate to induce positive DNA supercoiling
Nature Structural & Molecular Biology, 2019Anna H. Bizard +6 more
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