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The benefit of DNA supercoiling during replication.
Biochemical Society Transactions, 2013 J. Schvartzman +3 more
semanticscholar +1 more source
DNA supercoiling impacts alternative transcription start site selection in yeast
Elgood Hunt E, Vivori C, van Werven FJ.
europepmc +1 more source
DNA supercoiling modulates eukaryotic transcription in a gene-orientation dependent manner
Morao AK +4 more
europepmc +1 more source
Membrane translocation and refolding mitochondrial proteins [PDF]
, 1990 Hartl, Franz-Ulrich +2 more
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Biophysical Chemistry, 1988
DNA topoisomerase mutants of Escherichia coli and Saccharomyces cerevisiae were used to study the topological state of intracellular DNA. In E. coli, it is shown that switching off the gene topA encoding DNA topoisomerase I leads to an increase in the degree of negative supercoiling of intracellular DNA and inhibition of the growth of the cells: a d ...
G N, Giaever, L, Snyder, J C, Wang
exaly +3 more sources
DNA topoisomerase mutants of Escherichia coli and Saccharomyces cerevisiae were used to study the topological state of intracellular DNA. In E. coli, it is shown that switching off the gene topA encoding DNA topoisomerase I leads to an increase in the degree of negative supercoiling of intracellular DNA and inhibition of the growth of the cells: a d ...
G N, Giaever, L, Snyder, J C, Wang
exaly +3 more sources
Negative DNA supercoiling induces genome-wide Cas9 off-target activity
Molecular Cell, 2023 CRISPR-Cas9 is a powerful gene-editing technology; however, off-target activity remains an important consideration for therapeutic applications. We have previously shown that force-stretching DNA induces off-target activity and hypothesized that ...
Marcello Maresca +2 more
exaly +2 more sources
Long-Distance Cooperative and Antagonistic RNA Polymerase Dynamics via DNA Supercoiling
Cell, 2019 Genes are often transcribed by multiple RNA polymerases (RNAPs) at densities that can vary widely across genes and environmental conditions. Here, we provide in vitro and in vivo evidence for a built-in mechanism by which co-transcribing RNAPs display ...
Sangjin Kim +2 more
exaly +2 more sources