Results 1 to 10 of about 28,674 (272)
DNA topoisomerases participate in fragility of the oncogene RET. [PDF]
PLoS ONE, 2013 Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Laura W Dillon +4 more
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EcoSal Plus, 2015 DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are two types, I and II, classified according to whether they make transient single- or double-stranded breaks in DNA. Their reactions generally involve the passage of a single- or double-strand segment of DNA through this transient break, stabilized by DNA-protein ...
Bush NG, Evans-Roberts K, Maxwell A.
europepmc +3 more sources
Our Evolving Understanding of the Mechanism of Quinolones [PDF]
Antibiotics, 2018 The maintenance of DNA supercoiling is essential for the proper regulation of a plethora of biological processes. As a consequence of this mode of regulation, ahead of the replication fork, DNA replication machinery is prone to introducing supercoiled ...
Arnaud Gutierrez +2 more
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DNA-Topology Simplification by Topoisomerases [PDF]
Molecules, 2021 The topological properties of DNA molecules, supercoiling, knotting, and catenation, are intimately connected with essential biological processes, such as gene expression, replication, recombination, and chromosome segregation. Non-trivial DNA topologies
Andreas Hanke +2 more
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DNA topoisomerases as molecular targets for anticancer drugs [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The significant role of topoisomerases in the control of DNA chain topology has been confirmed in numerous research conducted worldwide. The prevalence of these enzymes, as well as the key importance of topoisomerase in the proper functioning of cells ...
Kamila Buzun +3 more
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Computational and Structural Biotechnology Journal, 2023 Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription.
Matic Pavlin +3 more
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Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate [PDF]
Nature Communications, 2018 Type II DNA topoisomerases (Top2s) direct the passage of one DNA duplex through another, which is important for resolving DNA entanglements. Here the authors combine X-ray crystallography and MD simulations and present the structure of the human Top2 DNA-
Shin-Fu Chen +7 more
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eLife, 2022 Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a second duplex.
Joshua Jeong +4 more
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Topoisomerases as Targets for Novel Drug Discovery [PDF]
PharmaceuticalsDNA topoisomerases (topo) are essential enzymes that maintain the integrity of the genome by regulating the topological state of DNA during replication, transcription, recombination and repair [...]
Andrej Perdih
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DNA binding and cleavage mechanism of DNA topoisomerase VI, an evolutionary counterpart of Spo11/Wadjet/Gabija systems [PDF]
Structural DynamicsType II topoisomerases resolve DNA supercoiling and chromosome entanglements. Type IIB topoisomerases, exemplified by Top6, are used by plants and archaea to support endoreduplication and cell proliferation, respectively; homologs of Top6 subunits ...
Daniel E Richman +7 more
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