Results 21 to 30 of about 79,794 (267)

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals [PDF]

, 2016
DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain.
Ahmad, Muzammil, Ciaramella, Maria, Debat, Hélène, Gorospe, Myriam, Hsieh, Tao-Shih, Lee, Seung Kyu, Leng, Fenfei, Li, Wen, Martindale, Jennifer L, Nadal, Marc, Niu, Hengyao, Pommier, Yves, Shen, Weiping, Siaw, Grace Ee-Lu, Tse-Dinh, Yuk-Ching, Wang, Quan, Wang, weidong, Xu, Dongyi, Xu, Yutong, Zhang, Hongliang, Zou, Sige   +20 more
core   +3 more sources

Purification and characterization of type I DNA topoisomerase fromLentinus edodes [PDF]

FEMS Microbiology Letters, 1986
Abstract Type I DNA topoisomerase was purified from the lower eukaryote Lentinus edodes . Like the topoisomerase I from other eukaryotic cells, the L. edodes enzyme removed both positive and negative superhelical turns. The M r of the enzyme was determined to be 71,500 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).
H. Kono, N. Habuka, K. Shishido
openaire   +2 more sources

Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes [PDF]

, 2019
The convergence of two DNA replication forks creates unique problems during DNA replication termination. In E. coli and SV40, the release of torsional strain by type II topoisomerases is critical for converging replisomes to complete DNA synthesis, but ...
Baxter, Jonathan, Deegan, Tom D, Labib, Karim P M, Ortiz Bazán, María Ángeles, Yeeles, Joseph T P   +4 more
core   +6 more sources

Inhibitory Activities ofHelichrysum. Taxa on Mammalian Type I DNA Topoisomerase [PDF]

Pharmaceutical Biology, 2006
AbstractDNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalyzing the concerted breakage and rejoining of DNA strands during normal cellular growth. During the past few years, there has been considerable pharmacological interest in these enzymes because the inhibitors of DNA topoisomerases represent
Kucukoglu, O., Kamataki, T., Ozturk, B., Topcu, Z.   +3 more
openaire   +1 more source

Overexpression of Type I Topoisomerases Sensitizes Yeast Cells to DNA Damage [PDF]

Journal of Biological Chemistry, 2001
DNA topoisomerases play essential roles in many DNA metabolic processes. It has been suggested that topoisomerases play an essential role in DNA repair. Topoisomerases can introduce DNA damage upon exposure to drugs that stabilize the covalent protein-DNA intermediate of the topoisomerase reaction. Lesions in DNA are also able to trap topoisomerase-DNA
J L, Nitiss, K C, Nitiss, A, Rose, J L, Waltman   +3 more
openaire   +2 more sources

DNA topoisomerase inhibitors: biflavonoids from Ouratea species

Brazilian Journal of Medical and Biological Research, 2002
Topoisomerase inhibitors are agents with anticancer activity. 7"-O-Methyl-agathisflavone (I) and amentoflavone (II) are biflavonoids and were isolated from the Brazilian plants Ouratea hexasperma and O. semiserrata, respectively.
N.F. Grynberg, M.G. Carvalho, J.R. Velandia, M.C. Oliveira, I.C. Moreira, R. Braz- Filho, A. Echevarria   +6 more
doaj   +1 more source

Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. [PDF]

PLoS Genetics, 2008
Topoisomerases are enzymes with crucial functions in DNA metabolism. They are ubiquitously present in prokaryotes and eukaryotes and modify the steady-state level of DNA supercoiling.
Frank Hartung, Stefanie Suer, Alexander Knoll, Rebecca Wurz-Wildersinn, Holger Puchta   +4 more
doaj   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

Mechanism and Specificity of DNA Strand Exchange Catalyzed by Vaccinia DNA Topoisomerase Type I [PDF]

Biochemistry, 2010
The type I DNA topoisomerase from vaccinia virus (vTopo) forms a reversible covalent 3'-phosphotyrosyl linkage with a single strand of duplex DNA at the preferred sequence 5'-(C/T)CCTTp downward arrowN(-1)N(-2)N(-3)-3'. The enzyme-DNA covalent adduct is recombinogenic in cells, because the nicked strand downstream of the cleavage site can dissociate ...
Mary R, Stahley, James T, Stivers
openaire   +2 more sources

Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars

Antibiotics, 2021
Quinolone resistance in bacterial pathogens has primarily been associated with mutations in the quinolone resistance-determining regions (QRDRs) of bacterial type-II topoisomerases, which are DNA gyrase and topoisomerase IV. Depending on the position and
Aqsa Shaheen, Anam Tariq, Mazhar Iqbal, Osman Mirza, Abdul Haque, Thomas Walz, Moazur Rahman   +6 more
doaj   +1 more source