The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing [PDF]
, 2008 Joseph E. Deweese, Neil Osheroff
openalex +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. [PDF]
Elife, 2022 Huiting W +16 more
europepmc +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source
DNA topoisomerase II sites in the histone H4 gene during the highly synchronous cell cycle of Physarum polycephalum [PDF]
, 1998 V. Borde, M. Duguet
openalex +1 more source
Can DNA Topoisomerases Be Ribonucleases? [PDF]
Cell, 1997 DNA topoisomerases catalyze changes in the linkage of DNA strands through a concerted mechanism of DNA strand cleavage and ligation reactions (for review, seeWang 1996xWang, J.C. Annu. Rev. Biochem. 1996; 65: 635–692Crossref | PubMedSee all ReferencesWang 1996).
openaire +2 more sources
Long‐term remission of type B insulin resistance syndrome with immunotherapy: A case report
Journal of Diabetes Investigation, EarlyView.ABSTRACT We report long‐term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55‐year‐old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high‐dose insulin and recombinant ...
Erika Egawa +3 more
wiley +1 more source
DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. [PDF]
Bioessays, 2021 McKie SJ, Neuman KC, Maxwell A.
europepmc +1 more source
Molecular Microbiology, EarlyView.Bacillus subtilis RNase HII corrects ribonucleotide errors and mismatched ribonucleotides, but not damaged ribonucleotides. Mismatched ribonucleotides would also serve as substrates for mismatch repair while damaged ribonucleotides would be addressed through base excision repair.
Julianna R. Cresti, Lyle A. Simmons
wiley +1 more source
Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways [PDF]
, 2012 Ksenia Terekhova +3 more
openalex +1 more source