Results 41 to 50 of about 121,903 (271)
Molecular Therapy: Methods & Clinical Development, 2020 CD19-specific chimeric antigen receptor (CAR19) T cells, generated using viral vectors, are an efficacious but costly treatment for B cell malignancies.
David C. Bishop +7 more
doaj +1 more source
Functional genomics with a comprehensive library of transposon mutants for the sulfate-reducing bacterium Desulfovibrio alaskensis G20. [PDF]
, 2014 UnlabelledThe genomes of sulfate-reducing bacteria remain poorly characterized, largely due to a paucity of experimental data and genetic tools. To meet this challenge, we generated an archived library of 15,477 mapped transposon insertion mutants in the
Arkin, Adam P +11 more
core +2 more sources
Sleeping Beauty transposon integrates into non-TA dinucleotides
Mobile DNA, 2018 Background Sleeping Beauty transposon (SB) has become an increasingly important genetic tool for generating mutations in vertebrate cells. It is widely thought that SB exclusively integrates into TA dinucleotides.
Yabin Guo, Yin Zhang, Kaishun Hu
doaj +1 more source
DNA Transposons and the Evolution of Eukaryotic Genomes [PDF]
Annual Review of Genetics, 2007 Transposable elements are mobile genetic units that exhibit broad diversity in their structure and transposition mechanisms. Transposable elements occupy a large fraction of many eukaryotic genomes and their movement and accumulation represent a major force shaping the genes and genomes of almost all organisms.
Cédric, Feschotte, Ellen J, Pritham
openaire +2 more sources
Squalen, 2013 Transposon is well-known as mobile element found abundant both in prokaryote and eukaryote genomes. In bacteria, transposon (famous name of a transposable DNA) could jump from chromosome to plasmid and its contrary.
Mochamad Untung Kurnia Agung +1 more
doaj +1 more source
eLife, 2016 DNA methylation is extensively remodeled during mammalian gametogenesis and embryogenesis. Most transposons become hypomethylated, raising the question of their regulation in the absence of DNA methylation.
Marius Walter +3 more
doaj +1 more source
Genome-Wide Transposon Screen of a Pseudomonas syringae mexB Mutant Reveals the Substrates of Efflux Transporters. [PDF]
, 2019 Bacteria express numerous efflux transporters that confer resistance to diverse toxicants present in their environment. Due to a high level of functional redundancy of these transporters, it is difficult to identify those that are of most importance in ...
Deutschbauer, Adam M +4 more
core +1 more source
Genome-wide analysis of
BMC Genomics, 2009 Background Tol2, a member of the hAT family of transposons, has become a useful tool for genetic manipulation of model animals, but information about its interactions with vertebrate genomes is still limited.
Parinov Sergey +4 more
doaj +1 more source
A comparative study of Tam3 and Ac transposition in transgenic tobacco and petunia plants [PDF]
, 1989 Transposition of the Anthirrinum majus Tam3 element and the Zea mays Ac element has been monitored in petunia and tobacco plants. Plant vectors were constructed with the transposable elements cloned into the leader sequence of a marker gene ...
A Day +41 more
core +4 more sources
eLife, 2021 In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in part through the co-transcriptional gene silencing of transposon insertions.
Evelyn L Eastwood +8 more
doaj +1 more source