Results 11 to 20 of about 3,025,811 (189)

The next-generation DNA vaccine platforms and delivery systems: advances, challenges and prospects

Frontiers in Immunology
Vaccines have proven effective in the treatment and prevention of numerous diseases. However, traditional attenuated and inactivated vaccines suffer from certain drawbacks such as complex preparation, limited efficacy, potential risks and others.
Bowen Lu, Bowen Lu, Bowen Lu, Jing Ming Lim, Boyue Yu, Siyuan Song, Praveen Neeli, Navid Sobhani, Pavithra K, Srinivasa Reddy Bonam, Rajendra Kurapati, Junnian Zheng, Junnian Zheng, Dafei Chai, Dafei Chai, Dafei Chai   +15 more
doaj   +2 more sources

DNA Vaccines [PDF]

Critical Reviews™ in Immunology, 1998
DNA vaccination against infectious diseases has created a new field of applied molecular immunology. cDNAs for 'protective' protein epitopes can be inserted into vectors containing strong mammalian promoters for high expression. Here we discuss the mechanisms of DNA vaccination and the successful and sometimes unsuccessful applications of DNA ...
W C, Lai, M, Bennett
  +7 more sources

DNA Vaccines: History, Molecular Mechanisms and Future Perspectives.

Journal of Molecular Biology, 2023
The history of DNA vaccine began as early as the 1960s with the discovery that naked DNA can transfect mammalian cells in vivo. In 1992, the evidence that such transfection could lead to the generation of antigen-specific antibody responses was obtained ...
S. Pagliari, Barbara Dema, Alexandra Sánchez-Martínez, Gerardo Montalvo Zurbia Flores, C. Rollier   +4 more
semanticscholar   +1 more source

A brief review on DNA vaccines in the era of COVID-19

Future Virology, 2021
This article provides a brief overview of DNA vaccines. First, the basic DNA vaccine design strategies are described, then specific issues related to the industrial production of DNA vaccines are discussed, including the production and purification of ...
Maryam Shafaati, M. Saidijam, M. Soleimani, F. Hazrati, Rasoul Mirzaei, Bagher Amirheidari, Hamid Tanzadehpanah, Sajad Karampoor, Sima Kazemi, B. Yavari, Hanie Mahaki, Mohsen Safaei, F. Rahbarizadeh, Pouria Samadi, Yaghoub Ahmadyousefi   +14 more
semanticscholar   +1 more source

DNA vaccines for SARS-CoV-2: toward third-generation vaccination era

Expert Review of Vaccines, 2021
Introduction: Coronavirus outbreak 2019 (COVID-19) has affected all the corners of the globe and created chaos to human life. In order to put some control on the pandemic, vaccines are urgently required that are safe, cost effective, easy to produce, and
Vivek P. Chavda, R. Pandya, V. Apostolopoulos   +2 more
semanticscholar   +1 more source

Brucella abortus RB51 lipopolysaccharide influence as an adjuvant on the therapeutic efficacy of HPV16 L1 and HPV16 E7 DNA vaccines [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Human papillomavirus (HPV) is a primary contributing agent of cervical cancer. Eradication of HPV-related infections requires therapeutic strategies.
Masoumeh Shirmohammadi, Hoorieh Soleimanjahi, Zahra Kianmehr, Hesam Karimi, Sussan Kabudanian Ardestani   +4 more
doaj   +1 more source

DNA Vaccines

Japanese Journal of Pharmacology, 2000
DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages
Y, Koide, T, Nagata, A, Yoshida, M, Uchijima   +3 more
  +8 more sources

DNA Vaccination

Current Protocols in Human Genetics, 2003
AbstractThis unit details some of the key methods for setting up and testing DNA vaccines in animal models. The basic procedures are discussed, as well as alternative methods that have been developed over the past several years. The gives step‐by‐step instructions for administering the DNA vaccine via intramuscular injection of the quadriceps muscle ...
Jeffrey B, Ulmer, Rino, Rappuoli
  +9 more sources

Comparative analysis of existing platforms for the development of vaccines against dangerous and extremely dangerous viral infections with pandemic potential

Биопрепараты: Профилактика, диагностика, лечение, 2021
The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko, T. E. Sizikova, V. N. Lebedev, S. V. Borisevich   +3 more
doaj   +1 more source

DNA vaccines

Allergy, 1999
Chronic infections with hepatitis B (HBV) and hepatitis C (HCV) virus are worldwide problems often leading to the development of chronic liver disease and hepatocellular carcinoma. Genetic immunizations with DNA encoding for structural and nonstructural proteins of HCV and HBV in experimental mice generate a broad base CD4+ and CD8+ cellular immune ...
H L, Spiegelberg, E, Raz
  +8 more sources