Results 121 to 130 of about 94,936 (269)

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

, 2016
Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital ...
Kim EY, Seo JH, Oh KS, Yuk SH, Lee K, Kim KI, Lee HJ, Park DY, Yoon BD   +8 more
core  

Extracellular vesicles in pharmacology: Innovations in drug delivery and therapeutic applications in cancer

British Journal of Pharmacology, EarlyView.
Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka, Georgios Sivvas, Evangelia Papadimitriou, Constantinos M. Mikelis   +3 more
wiley   +1 more source

Proteomic Analysis Reveals AMPKα‐Mediated Antiandrogen Resistance via Ferroptosis Suppression in Prostate Cancer

Cancer Science, EarlyView.
Antiandrogen‐resistant prostate cancer cells acquire ferroptosis resistance through AMPKα activation and upregulation of ferroptosis suppressor pathways. This adaptive state creates a therapeutic vulnerability, as GPX4 inhibition, particularly in combination with AMPKα inhibition, effectively suppresses the growth of resistant cells.
Masaki Shiota, Tokiyoshi Tanegashima, Takahiko Hajime, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Satoshi Kobayashi, Takashi Matsumoto, Masatoshi Eto   +8 more
wiley   +1 more source

Integrating Supragingival Scaling and Biofilm Management Into Breast Cancer Patients' Care

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective The study was designed as a quasi‐experimental clinical trial to evaluate the impact of chemotherapy on periodontal conditions, haematology and salivary flow in patients with breast cancer and gingivitis, after supragingival scaling.
Kelly R. V. Villafuerte, Francisco J. Candido Dos Reis, Hélio H. A. Carrara, Cristhiam H. Martinez, Daniela B. Palioto   +4 more
wiley   +1 more source

Regularization Approaches for High‐Dimensional Cox Models: A Case Study in Triple‐Negative Breast Cancer

International Statistical Review, EarlyView.
Summary In high‐dimensional survival analysis, effective variable selection is crucial both for model interpretation and predictive performance. This paper investigates Cox regression with lasso and adaptive lasso penalties in genomic datasets where covariates far outnumber observations.
Pilar González‐Barquero, Rosa E. Lillo, Álvaro Méndez‐Civieta   +2 more
wiley   +1 more source

Docetaxel induced activation of GSDME pathway and pyroptosis enhance immune lethality in prostate cancer cells

Journal of Experimental & Clinical Cancer Research
Background Immunotherapy has emerged as a promising approach in prostate cancer treatment, albeit with less efficacy compared to lung and esophageal cancers.
Ruoyang Liu, Long Zhang, Guoqing Xie, Xiang Li, Yu Liu, Ningyang Li, Aravind Raveendran, Yuankang Feng, Fubo Lu, Xiyue Deng, Junyi Li, Jinjian Yang, Zhenlin Huang, Zhankui Jia   +13 more
doaj   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Inhibition of P‐glycoprotein using photoimmunotherapy in peritoneal metastasis mouse model

Photochemistry and Photobiology, EarlyView.
Photoimmunotherapy (PIT) using photoimmunoconjugates (PICs) can inhibit the function of the ATP‐binding cassette (ABC) transporter P‐glycoprotein (P‐gp) in a mouse model of peritoneal carcinomatosis. Sterile‐filtered PIC was administered in vivo via intraperitoneal (IP) injection 20 days after IP tumor cell implantation of P‐gp‐overexpressing NCI/ADR ...
Kaitlyn A. Moore, Brian Schnoor, Kathryn L. McNaughton, Idrisa Rahman, Benjamin D. Powers, Dana M. Roque, Huang‐Chiao Huang   +6 more
wiley   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Gastric Metastasis of Uterine Leiomyosarcoma Detected During Surveillance Endoscopy and Resected by Endoscopic Submucosal Dissection After Multiple Metachronous Metastases: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Uterine leiomyosarcoma (uLMS) is a rare, aggressive uterine malignancy that usually metastasizes hematogenously, whereas gastrointestinal involvement is uncommon. A 69‐year‐old woman with uLMS treated by hysterectomy and adjuvant chemotherapy developed metachronous lung, sigmoid colon, gallbladder, and abdominal wall metastases.
Yuiko Nagasawa, Takahiro Hiratsuka, Daisuke Minezaki, Wataru Miyoshino, Ryo Ogawa, Tomonori Akagi, Hidefumi Shiroshita, Yoshitake Ueda, Kazuhiro Mizukami, Masafumi Inomata   +9 more
wiley   +1 more source