Results 141 to 150 of about 94,936 (269)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, Volume 20, Issue 9, Page 2280-2295, September 2026.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Synergistic toxicity and clinical prioritization of docetaxel combined with nintedanib for non-small cell lung cancer: a real-world safety analysis using the FAERS database. [PDF]

Front Oncol
Zhang Q, Feng Q, Lei S, Yang W, Zhang W, Liu X.   +5 more
europepmc   +1 more source

Prospective Trial on Tolerability and Efficacy of Adjuvant Nedaplatin Plus Docetaxel for Non-Small Cell Lung Cancer. [PDF]

Cancer Sci
The flow of this trial and the treatment schedule of adjuvant chemotherapy with nedaplatin plus docetaxel for completely resected non‐small cell lung cancer (NSCLC) (A). The primary endpoint of this study was tolerability, assessed by the completion rate of the planned four chemotherapy cycles. As a result, it was 74.3%, exceeding that reported for the
Teramoto K, Kaku R, Igarashi T, Hashimoto M, Kitamura S, Motoishi M, Suzumura Y, Sawai S, Daigo Y, Hanaoka J.   +9 more
europepmc   +2 more sources

Years of Life Lost From Metastatic Prostate Cancer According to Treatment Era and Race/Ethnicity. [PDF]

Prostate
ABSTRACT Introduction Randomized trials demonstrated improved survival in metastatic prostate cancer (mPCa) with the adoption of several systemic therapies. However, real‐world data validating this effect and quantifying its magnitude in years of life lost (YLL) according to race/ethnicity are unavailable. Methods In surveillance, epidemiology, and end
Quarta L, Petix M, Filzmayer M, Orlandi F, Polverino F, Goyal JA, Ferro M, Chun FKH, Micali S, Longo N, Shariat SF, Barletta F, Stabile A, Gandaglia G, Montorsi F, Saad F, Briganti A, Karakiewicz PI.   +17 more
europepmc   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, Volume 16, Issue 9, Page 1801-1812, September 2026.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

APUC-6 Genes as a Potential Prognostic and Predictive Biomarker in the CHAARTED Prostate Cancer Trial. [PDF]

JCO Precis Oncol
Shi X, Shetty AC, Wang J, Song Y, Sutera PA, Deek MP, Patel KR, Madan RA, Tang C, Proudfoot J, Davicioni E, Hussain A, Nguyen P, Sweeney C, Boytim E, Lacuna KP, Ryan CJ, Antonarakis ES, Tran PT, Hwang J.   +19 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Successful Management and Treatment Rechallenge Following Docetaxel-Induced Serpentine Supravenous Hyperpigmentation With Bullous Features: A Case Report. [PDF]

Clin Case Rep
Nair GR, Koutsis J, Poels D, Agar N, Warrier S, Kumar S.   +5 more
europepmc   +1 more source

Docetaxel induced pericardial effusion

, 2007
Docetaxel is a complex diterpene obtained from Taxus Brevifolia, and it is one of the most widely used anticancer agents. The main mechanism of citotoxic action depends on stabilization of microtubules leading to cell mitotic arrest.
Frezza AM, Rocci L, Santini D, Vincenzi B, Tonini G   +4 more
core  

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1368-1381, September 2026.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source