Results 111 to 120 of about 5,090,772 (358)

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

Metabolism of n-3 polyunsaturated fatty acids and modification of phospholipids in cultured rabbit aortic smooth muscle cells.

Journal of Lipid Research, 1985
The metabolism of the linolenic acid family (n-3) of fatty acids, e.g., linolenic, eicosapentaenoic, and docosahexaenoic acids, in cultured smooth muscle cells from rabbit aorta was compared to the metabolism of linoleic and arachidonic acids.
N Morisaki, T Kanzaki, Y Fujiyama, I Osawa, K Shirai, N Matsuoka, Y Saito, S Yoshida   +7 more
doaj  

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Rapeseeds a Rich Source of Polyunsaturated Fatty Acids

Proceedings, 2019
In human diet, polyunsaturated fatty acids (PUFA), have an essential role in optimal brain functions and stroke prevention, specially, omega-3 fatty acids, e.g., 9,12,15-linolenic acid (ALA, 18:3), 5,8,11,14,17-eicosapentaenoic acid (EPA, 20:5), and 4,7 ...
Cristina Emanuela Enăşcuţă, Elena Emilia Oprescu, Adrian Radu, Elena Radu, Marian Deaconu, Doru-Gabriel Epure, Mihai Gidea, Mihaela Niculescu   +7 more
doaj   +1 more source

Safety and efficacy of docosahexaenoic acid supplementation during neoadjuvant breast cancer therapy: Findings from the phase II, double‐blind, randomized controlled DHA‐WIN trial

International Journal of Cancer, EarlyView.
What's New? Omega‐3 docosahexaenoic acid (DHA) has shown pleiotropic anti‐cancer effects both in vitro and in animal models. However, clinical evidence of DHA efficacy is limited. This randomized, double‐blind, placebo‐controlled trial tested the efficacy of supplementation with DHA 4.4 g/day during 18 weeks of breast cancer neoadjuvant chemotherapy ...
Jaqueline Munhoz, Marnie Newell, Gilbert Bigras, Susan Goruk, Anil Abraham Joy, Sunita Ghosh, Kerry S. Courneya, Vera Mazurak, Claire M. Douglas, Xiaofu Zhu, Bohdarianna Zorniak, John Mackey, Judith Meza Junco, Julie Price Hiller, Karen King, Sanraj K. Basi, Catherine J. Field   +16 more
wiley   +1 more source

The impact of 60 days of ‐6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Reductions in skeletal muscle mitochondrial respiration following 60 days of bed rest explained by a decrease in mitochondrial content, but resulting in an increase in OPA1 and Drp1 mediated mitochondrial fission. Abstract It is unclear how skeletal muscle metabolism and mitochondrial function adapt to long duration bed rest and ...
John Noone, Anthony Damiot, Helena Kenny, Isabelle Chery, Alexandre Zahariev, Sylvie Normand, François Crampes, Isabelle de Glisezinski, Keith D. Rochfort, Claire Laurens, Marie‐Pierre Bareille, Chantal Simon, Audrey Bergouignan, Stéphane Blanc, Donal J. O'Gorman   +14 more
wiley   +1 more source

Omega-3 Fatty Acids Improve Recovery, whereas Omega-6 Fatty Acids Worsen Outcome, after Spinal Cord Injury in the Adult Rat [PDF]

, 2006
Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage ...
Curran, O. E., Dyall, Simon, Huang, W. L., King, V. R., Michael-Titus, A. T., Priestley, J. V.   +5 more
core   +1 more source

Association between multioil intravenous lipid emulsion and cholestasis in infants with gastrointestinal disorders: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Infants with gastrointestinal (GI) disorders are at risk for parenteral nutrition–associated cholestasis. A multioil intravenous lipid emulsion (MO ILE) contains less phytosterols and more arachidonic and docosahexaenoic acid (DHA) than 100% soybean oil lipid emulsion (SO ILE).
Lauren J. Lee, Esther S. Kim, Tahmineh Romero, Kara L. Calkins   +3 more
wiley   +1 more source

Docosahexaenoic acid: membrane modification and neurotrophic mechanisms

Oléagineux, Corps gras, Lipides, 2011
Docosahexaenoic acid (DHA, 22:6n-3) is highly enriched in the brain mainly in membrane phospholipids. Maintenance of a high DHA concentration in brain is essential for proper neuronal function, suggesting a unique requirement of this fatty acid for an ...
Kim Hee-Yong
doaj   +1 more source