Results 91 to 100 of about 2,732,817 (216)

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue

Current Research in Toxicology
On murine N2a cells, 7-ketocholesterol induced an oxiapotophagic mode of cell death characterized by oxidative stress (reactive oxygen species overproduction on whole cells and at the mitochondrial level; lipid peroxidation), apoptosis induction (caspase-
Aline Yammine, Imen Ghzaiel, Vivien Pires, Amira Zarrouk, Omar Kharoubi, Hélène Greige-Gerges, Lizette Auezova, Gérard Lizard, Anne Vejux   +8 more
doaj   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

DEVELOPMENT OF A COOKIE WITH ADDED OMEGA 3 FATTY ACIDS SOURCE AS FUNCTIONAL FOOD

Vitae, 2012
The present work aims at develop of a cookie with added omega 3. Three different commercial forms of omega 3 were evaluated as docosahexaenoic acid and ecoisapentaenoic acid (emulsion, powder and oil) at different omega 3 (ω3): omega 6 (ω6) ratios (1:5 ...
Iliana C. TORRES Q., Misael CORTÉS R., Kenneth R. CABRERA T.   +2 more
doaj  

Reversible alterations in fatty acid composition of heart muscle membrane phospholipids induced by epinephrine in rats fed different fats

Journal of Lipid Research, 1988
The effect of epinephrine on the fatty acid composition of heart muscle phospholipids was examined in rats fed diets containing 10% by weight of butter, corn oil, or cod liver oil.
V E Benediktsdottir, S Gudbjarnason
doaj   +1 more source

Transcriptomics Unveil Dsx1 as a Critical Regulator in Sexual Dimorphism of Crustaceans

Integrative Zoology, EarlyView.
Sexually dimorphic traits are involved in reproductive competition and are shaped by sex‐biased gene expression. This study identifies Dsx1 as a key male‐biased gene in Morinoia aosen and demonstrates through RNA interference that its disruption feminizes male‐specific T3 leg structures.
Yan Tong, Wenpei Xin, Zeyu Liu, Yami Zheng, Mengyi Huang, Hongguang Liu, Decai Lu, Wei Peng, Zhonge Hou   +8 more
wiley   +1 more source

Enrichment of docosahexaenoic acid from tuna oil via lipase-mediated esterification under pressurized carbon dioxide

, 2017
Docosahexaenoic acid (DHA); Ethanol; Lipozyme RM IM (Rhizomucor miehei); Near-supercritical carbon dioxide; Tuna oil fatty ...
김양하
core   +1 more source

A randomised controlled trial investigating the effect of n-3 long-chain polyunsaturated fatty acid supplementation on cognitive and retinal function in cognitively healthy older people: the Older People And n-3 Long-chain polyunsaturated fatty acids (OPAL) study protocol [ISRCTN72331636]. [PDF]

, 2006
The number of individuals with age-related cognitive impairment is rising dramatically in the UK and globally. There is considerable interest in the general hypothesis that improving the diet of older people may slow the progression of cognitive decline.
Hardy, Pollyanna, Rosemary Knight, Ann Truesdale, Clemens, Felicity, Hardy Pollyanna, Graham E Holder, Vickers Madge, Fletcher, Astrid E, Felicia A Huppert, Elbourne, Diana, Richards, Marcus, Knight, Rosemary, Fletcher Astrid E, Pollyanna Hardy, Madge Vickers, Vickers, Madge, Letley Louise, Letley, Louise, Dangour, Alan D, Felicity Clemens, Dangour Alan D, Ricardo Uauy, Louise Letley, Knight Rosemary, Diana Elbourne, Fasey, Nicky, Uauy, Ricardo, Uauy Ricardo, Holder, Graham E, Huppert Felicia A, Richards Marcus, Alan D Dangour, Truesdale Ann, Astrid E Fletcher, Marcus Richards, Elbourne Diana, Nicky Fasey, Clemens Felicity, Holder Graham E, Fasey Nicky, Truesdale, Ann, Huppert, Felicia A, Vickers, M, Richards, M, Elbourne, D, Hardy, P, Alan, D.D, Uauy, R, Holder, G.E, Clemens, F, Fletcher, A.E, Huppert, F.A, Truesdale, A, Fasey, N, Knight, R, Letley, L   +55 more
core   +4 more sources

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited.

PLoS ONE, 2014
ObjectiveWe aimed to investigate the association between baseline plasma fatty acids profile and the risk of future major cardiovascular events in patients with a history of ischaemic heart disease or ischemic stroke.MethodsBaseline plasma fatty acids as
Léopold K Fezeu, François Laporte, Emmanuelle Kesse-Guyot, Valentina A Andreeva, Jacques Blacher, Serge Hercberg, Pilar Galan   +6 more
doaj   +1 more source