Results 191 to 200 of about 4,193,737 (302)

Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice. [PDF]

Front Immunol, 2023
Pflumm D, Seidel A, Klein F, Groß R, Krutzke L, Kochanek S, Kroschel J, Münch J, Stifter K, Schirmbeck R.   +9 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Imaging of electric-field-induced domain structure in DyMnO 3 nanocrystals. [PDF]

Discov Nano
Najeeb MA, Morrison R, Mokhtar AH, Porter DG, Lichtenberg F, Bombardi A, Newton MC.   +6 more
europepmc   +1 more source

Novel nitrite reductase domain structure suggests a chimeric denitrification repertoire in the phylum Chloroflexi. [PDF]

Microbiologyopen, 2022
Schwartz SL, Momper L, Rangel LT, Magnabosco C, Amend JP, Fournier GP.   +5 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature. [PDF]

Turk J Biol
Yilmaz M, Sever B, Kutlu Y, Gül M, Okuducu C, Tavli S, Otsuka M, Fujita M, Haliloğlu T, Çiftçi H, Demirci H.   +10 more
europepmc   +1 more source

Domain Structure, Thermal and Mechanical Properties of Polycaprolactone-Based Multiblock Polyurethane-Ureas under Control of Hard and Soft Segment Lengths. [PDF]

Polymers (Basel), 2022
Bugrov AN, Gorshkova YE, Ivan'kova EM, Kopitsa GP, Pavlova AA, Popova EN, Smirnova VE, Smyslov RY, Svetlichnyi VM, Vaganov GV, Vasil'ev BV.   +10 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Constructing a Broad-Pore-Domain Structure of Adsorbents for Acteoside Adsorption. [PDF]

Polymers (Basel)
Ru W, Liu J, Xiong F, Sun Y, Zhang Y, Li Y, Lv Y, Li X.   +7 more
europepmc   +1 more source

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function. [PDF]

Int J Mol Sci, 2022
Mohammed F, Odintsova E, Chidgey M.
europepmc   +1 more source