Results 111 to 120 of about 43,876 (313)

Clinical Observation on Basal Ganglia Aphasia after Stroke Treated by Donepezil

康复学报, 2015
Objective:To evaluate the curative effect of donepezil on basal ganglia aphasia after stroke.Methods:A total of 37 patients with basal ganglia aphasia after stroke were randomly assigned to donepezil group (n=19) and control group (n=18).
Xi CHENG, Jinghui LAI, Zhifeng WANG, Yanling GAO, Xiaofeng CHEN, Ling LIN   +5 more
doaj  

The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention

Frontiers in Aging Neuroscience
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD).
Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu, Xiaozheng Liu   +7 more
doaj   +1 more source

Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

Journal of Pharmacological Sciences, 2017
Donepezil is a potent and selective acetylcholinesterase inhibitor developed for the treatment of Alzheimer's disease. In the present study, we investigated the responses of astrocytes to bradykinin, an inflammatory mediator, and the effect of donepezil ...
Kouki Makitani, Shota Nakagawa, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume   +4 more
doaj   +1 more source

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer’s disease (AD) agents.
L. Piemontese, Daniel Tomás, Asha Hiremathad, V. Capriati, E. Candeias, S. Cardoso, S. Chaves, M. A. Santos   +7 more
semanticscholar   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

The use or misuse of biomedical treatment approaches to autism [PDF]

, 2013
Introduction: The need for evidence based recommendations regarding biomedical approaches to autism was felt in view of the significant number of autistic children presenting within the Child Development Assessment Unit, Malta and the interest shown in ...
Farrugia, John Mary
core  

Effect of donepezil on transcranial magnetic stimulation parameters in Alzheimer's disease [PDF]

, 2018
INTRODUCTION: There is a need for a reliable, noninvasive biomarker for Alzheimer's disease (AD). We assessed whether short-latency afferent inhibition (SAI), a transcranial magnetic stimulation paradigm that assesses cholinergic circuits of the brain ...
Hammond, P, Hardy, CJ, Hwang, YT, Ridha, BH, Rocchi, L, Rossor, MN, Rothwell, J, Warren, JD   +7 more
core   +1 more source

Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers

Drug Design, Development and Therapy, 2020
Seok Kyu Yoon,1 Kyun-Seop Bae,1 Dong Hyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Hyeong-Seok Lim1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea ...
Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS   +5 more
doaj  

Effects of Donepezil on Clinical Symptoms, Language, and Executive Skills in Individuals with Autism Spectrum Disorder: A Systematic Review [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. This study assessed the potential efficacy of donepezil in treating autism spectrum disorder (ASD), a neurodevelopmental condition characterized by social communication difficulties and repetitive behaviors. Donepezil, primarily used to treat
Shahrokh Amiri, Shadi Farabi Maleki, Leila Mandaloo, Morteza Ghojazadeh, Manouchehr Seyedi Vafaee   +4 more
doaj   +1 more source

The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents

Biomolecules & Therapeutics, 2018
A previous study in humans demonstrated the sustained inhibitory effects of donepezil on acetylcholinesterase (AChE) activity; however, the effective concentration of donepezil in humans and animals is unclear.
C. Shin, H. Kim, Kwang-Ho Cha, D. Won, Ji-Yun Lee, S. Jang, U. Sohn   +6 more
semanticscholar   +1 more source