Results 111 to 120 of about 33,626 (230)

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Effect of Psychoeducational Intervention on Donepezil Retention Rate and Analysis of Reasons for the Discontinuation in Patients with Alzheimer’s Dementia: A Randomized Study

Patient Preference and Adherence, 2021
Tetsumasa Kamei,1 Hiroyuki Kobayashi,2,3 Maika Nishida,2 Kenzo Muramoto,2 Shohei Nishimoto2 1Shonan Fujisawa Tokushukai Hospital, Kanagawa, Japan; 2Eisai Co., Ltd., Medical Headquarters, Tokyo, Japan; 3Department of Neuropsychiatry, School of Medicine ...
Kamei T, Kobayashi H, Nishida M, Muramoto K, Nishimoto S   +4 more
doaj  

Accelerating real‐world prediction and research in Alzheimer's: The M3AD study

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Chronic diseases, including Alzheimer's disease (AD) and related dementia (ADRD), do not exist solely as isolated entities. Instead, they weave concomitant trajectories of multiple diseases, conditions, behaviors, and risks, mutually influencing each other's course and natural history, in ways yet unexplored.
Moïse Desvarieux, Tatjana Rundek, Habibul Ahsan, Javier Narvaez, Felipe Diaz, Daniel Malinsky, Luis Marco Ruiz, Maxim Topaz, Thomas Falconer, Karthik Natarajan, James Noble, Barbara Entwisle, Deepthi Puram, Tara Anand, Hsin Yi Chen, Xinzhuo Jiang, Yian Gu, Alan Cohen, Mary Beth Terry, Brandon Pierce, Howard Andrews, Emily Rogalsky, Shahla Farzana, George Gulotta, John Beard, Danielle Landron, Samuel L Volchenboum, Philippe Ravaud, Julie Johnson, Ezra Susser, Andrew Rundle, Ying Wei, Nick Tsinoremas, David Loewenstein, Linda Fried, Allison Aiello, Richard Mayeux, George Hripcsak   +37 more
wiley   +1 more source

Plasma inflammatory biomarker profiles across the Alzheimer's disease spectrum in the Bio‐Hermes cohort

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Inflammation contributes to Alzheimer's disease (AD), but its stage‐specific and amyloid‐dependent patterns remain unclear. METHODS We analyzed 964 participants from the Bio‐Hermes cohort (cognitively normal [CN] = 404, mild cognitive impairment [MCI] = 302, mild AD = 258). Plasma levels of 32 cytokines, neurofilament light chain (
Zain Hussain, Dominic Ng, Samuel Leighton, Fani Deligianni, Craig Ritchie, Jonathan Cavanagh   +5 more
wiley   +1 more source

A case of Diogenes Syndrome [PDF]

, 2013
Diogenes Syndrome is a syndrome of extreme selfneglect, domestic squalor, excessive hoarding, social withdrawal and refusal of all help and lack of concern regarding one’s personal residential situation. A case report of an 83 year old lady with mild
Ferry, Peter
core  

Wake‐promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Taylor J. Pedersen, Sabrina G. Clemens, Joseph R. Winer, Ashish Sharma, Neus Falgàs, Brendan P. Lucey, Brian A. Gordon, Erik S. Musiek   +7 more
wiley   +1 more source

Cost‐effectiveness and impact at scale of collaborative care and lecanemab for Alzheimer's disease

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 1, March 2026.
Abstract INTRODUCTION Advancements in disease‐modifying therapies and collaborative dementia care programs have created opportunities to transform care for people with Alzheimer's disease. METHODS We modeled people aged 71 across three scenarios: 18 months of lecanemab, collaborative care, and combined interventions.
Kelly J. Atkins, James G. Kahn, Katherine L. Possin   +2 more
wiley   +1 more source

LC‐HESI‐MS/MS Profiling and Evaluation of Antioxidant, Anti‐Inflammatory, Anti‐α‐Amylase, and Anti‐Acetylcholinesterase Activities of Rhus tripartitum L. Leaf Extract: In Vitro and In Silico Studies

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study aims to assess the biological characteristics of Rhus tripartitum leaves and identify their promising biomolecules. The numerous extracts of R. tripartitum leaves were evaluated, in vitro, for their phytochemical profile and antioxidant, anti‐acetylcholinesterase, α‐amylase, and anti‐inflammatory activities. The methanolic and ethyl
Raoudha Ben Ameur, Imen Rekik, Nourhène Hamdaoui, Siwar Soltani, Nathan Téné, Michel Treilhou, Mongi Saoudi, Noureddine Allouche   +7 more
wiley   +1 more source

Comparison of In Silico AChE Inhibitory Potentials of Some Donepezil Analogues

Pharmata
Cholinesterases are important in ensuring hemostasis in our body. Excessive increase in cholinesterase function causes various cholinergic dysfunctions. Alzheimer's is a disease characterized by loss of cholinergic activity, which is especially common in
Mehmet Koca
doaj  

Therapeutic Effect of Donepezil on Neuroinflammation and Cognitive Impairment after Moderate Traumatic Brain Injury

Life
Background: Despite the important clinical issue of cognitive impairment after moderate traumatic brain injury (TBI), there is currently no suitable treatment.
Dong Hyuk Youn, Younghyurk Lee, Sung Woo Han, Jong-Tae Kim, Harry Jung, Gui Seung Han, Jung In Yoon, Jae Jun Lee, Jin Pyeong Jeon   +8 more
doaj   +1 more source