A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease [PDF]
, 2013 Copyright © 2013 IBRO. Published by Elsevier Ltd.
Barak +56 more
core +1 more source
TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg
Frontiers in Pharmacology, 2018 Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems.
Jian-Feng Liu, Jian-Feng Liu, Jun-Xu Li
doaj +1 more source
Dopamine agonists for the treatment of cocaine dependence.
Cochrane Database of Systematic Reviews, 2015 BACKGROUND Cocaine misuse is a disorder for which no pharmacological treatment of proven efficacy exists. Advances in neurobiology could guide future medication development.
S. Minozzi +7 more
semanticscholar +1 more source
Prevention of OHSS – dopamine agonists
Reproductive BioMedicine Online, 2009 Ovarian hyperstimulation syndrome (OHSS) is in iatrogenic complication of ovulation induction, which may seriously affect the patient's health, with 0.1-2.0% of the patients developing severe forms of the syndrome. OHSS signs and symptoms are direct consequences of fluid shift from capillaries to the third space due to increased vascular permeability ...
Juan A. Garcia-Velasco +5 more
openaire +4 more sources
Prolactinomas Resistant to Treatment With Dopamine Agonists: Long-Term Follow-Up of Six Cases
Frontiers in Endocrinology, 2018 Introduction: Prolactinomas are preferentially treated with dopamine agonists. However, a few adenomas are resistant to this treatment.Objective: To evaluate the characteristics of patients with resistance to dopamine agonists in the long-term.Method: A ...
Maria de Fátima de Magalhães Gonzaga +11 more
doaj +1 more source
Representation learning with reward prediction errors [PDF]
arXiv, 2021 The Reward Prediction Error hypothesis proposes that phasic activity in the midbrain dopaminergic system reflects prediction errors needed for learning in reinforcement learning. Besides the well-documented association between dopamine and reward processing, dopamine is implicated in a variety of functions without a clear relationship to reward ...
arxiv
Dopamine and Alcohol Dependence: From Bench to Clinic [PDF]
, 2016 Alcohol dependence, a chronic relapsing psychiatric disorder, is a major cause of mortality and morbidity. The role of dopamine in alcohol‐induced reward as well in the development of alcohol dependence is reviewed herein.
Ericson, Mia +3 more
core +1 more source
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists
Science, 2017 A strategy for drug discovery Dopamine receptors are G protein-coupled receptors implicated in many neurological disorders. Different families of dopamine receptors are involved in different signaling pathways, so specificity is a key goal of ...
Sheng Wang +10 more
semanticscholar +1 more source
Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor
Angewandte Chemie, EarlyView.A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth +9 more
wiley +2 more sources
Progress in the study of Dopamine Receptor Agonists for Brain Protection after Ischemic Brain Injury
Zhongguo cuzhong zazhi: Ischemic brain injury comprises 87% of all brain injuries and typically results in severe functional impairments. Dopamine, the most abundant catecholamine neurotransmitter in the brain, is intimately linked with autonomous movement, emotion, sleep ...
ZHANG Linyao1, LIU Lixu1,2
doaj +1 more source