PLoS ONE, 2013 ObjectiveBrain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are therapeutically beneficial.
Gene-Jack Wang +12 more
doaj +2 more sources
In Vitro Neurochemical Assessment of Methylphenidate and Its “Legal High” Analogs 3,4-CTMP and Ethylphenidate in Rat Nucleus Accumbens and Bed Nucleus of the Stria Terminalis [PDF]
Frontiers in Psychiatry, 2018 3,4-dichloromethylphenidate (3,4-CTMP) and ethylphenidate are new psychoactive substances and analogs of the attention deficit medication methylphenidate. Both drugs have been reported on online user fora to induce effects similar to cocaine.
Colin Davidson +4 more
doaj +5 more sources
Clonorchis sinensis dopamine transporter (CsDAT) facilitates dopamine uptake. [PDF]
Parasites Hosts Dis<i>Clonorchis sinensis</i> is a liver fluke that causes clonorchiasis, a significant public health concern in East Asia, closely associated with hepatobiliary diseases. Dopamine is an essential neurotransmitter involved in neuromuscular signaling, and its uptake by trematodes may contribute to parasite physiology and survival.
Lee WJ, Kim SJ, Lee WK, Han JH, Cha SH.
europepmc +2 more sources
Dopamine-Serotonin Transporter Disease
Pediatric Neurology Briefs, 2013 Investigators at the Hospital for Sick Children, University of Toronto, Canada report 8 children of a consanguineous Saudi Arabian family who had a similar movement disorder, with autosomal recessive inheritance and a mutation in the SLC18A2 gene that ...
J Gordon Millichap
doaj +3 more sources
Rats Lacking the Dopamine Transporter Display Inflexibility in Innate and Learned Behavior [PDF]
BiomedicinesPlaying a key role in the organization of striatal motor output, the dopamine (DA)-ergic system regulates both innate and complex learned behaviors.
Anastasia Belskaya +6 more
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Sex-Specific, Intermediate Behavioral Phenotypes in Heterozygous Dopamine Transporter Mutant DAT T356M Mice. [PDF]
Genes Brain BehavHarris E +4 more
europepmc +3 more sources
Vascular parkinsonism showing dopamine transporter scan findings mimicking those of Parkinson's disease [PDF]
eNeurologicalSciDopamine transporter (DAT) scan is important in the diagnosis of Parkinson's disease (PD). We herein report a patient with vascular parkinsonism (VP) who showed dopamine transporter (DAT) scan findings which mimicked those typically seen in patients with
Hirotaka Sakuramoto +3 more
doaj +2 more sources
Threonine-53 Phosphorylation of Dopamine Transporter Dictates κ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward. [PDF]
J NeurosciDurairaj RV, Ramamoorthy S, Jayanthi LD.
europepmc +3 more sources
Dopamine transporter interaction with blockers and transportable substrates: insights from kinetics study [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Competition kinetic analysis was performed to examine the interaction mechanism of the dopamine transporter with dopamine, (S)-amphetamine, and cocaine, which play a central role in drug abuse phenomena connected with the dopaminergic system.
Vladimir Stepanov
doaj +1 more source
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. [PDF]
PLoS Biology, 2005 Brain dopamine is critically involved in movement control, and its deficiency is the primary cause of motor symptoms in Parkinson disease. Here we report development of an animal model of acute severe dopamine deficiency by using mice lacking the ...
Tatyana D Sotnikova +5 more
doaj +2 more sources