Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones
Frontiers in Cellular Neuroscience, 2022 Mutations in the dopamine transporter gene (SLC6A3) have been implicated in many human diseases. Among these is the infantile parkinsonism-dystonia known as Dopamine Transporter Deficiency Syndrome (DTDS).
Charles Sutton +12 more
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Restoration of the Dopamine Transporter through Cell Therapy Improves Dyskinesia in a Rat Model of Parkinson's Disease. [PDF]
PLoS ONE, 2016 The dyskinesia of Parkinson's Disease is most likely due to excess levels of dopamine in the striatum. The mechanism may be due to aberrant synthesis but also, a deficiency or absence of the Dopamine Transporter.
D Tomas +5 more
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Is dopamine transporter gene effective on therapeutic response of methylphenidate in ADHD patients? [PDF]
Reviews in Clinical Medicine, 2015 Attention-deficit/hyperactivity disorder (ADHD) is the most common neuropsychiatric illness, which affects about 5% of children worldwide. An 80% genetic background is responsible for ADHD due to its appearance in familial relationships.
Fatemeh Moharrari, Soheila Barabadian
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Molecular Mechanism of Dopamine Transport by Human Dopamine Transporter [PDF]
Structure, 2015 Dopamine transporters (DATs) control neurotransmitter dopamine (DA) homeostasis by reuptake of excess DA, assisted by sodium and chloride ions. The recent resolution of DAT structure (dDAT) from Drosophila permits us for the first time to directly view the sequence of events involved in DA reuptake in human DAT (hDAT) using homology modeling and full ...
Cheng, Mary Hongying, Bahar, Ivet
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Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence. [PDF]
PLoS ONE, 2015 Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing ...
Che-Hung Yen +11 more
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Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain [PDF]
, 2010 The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters.
A Bonci +133 more
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Substrates dissociate dopamine transporter oligomers [PDF]
Journal of Neurochemistry, 2007 AbstractSubstrate‐induced endocytic trafficking of dopamine transporter (DAT) has been observed, but little is known about the regulation of DAT oligomerization by substrate. The present study investigates the effect on substrates on DAT oligomerization and explores a potential link with the presence of DAT at the cell surface in human embryonic kidney
Nianhang, Chen, Maarten E A, Reith
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Identification of novel target molecules of l-menthol
Heliyon, 2021 The present study used a binding assay to identify novel target biomolecules of l-menthol ([−]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM l-menthol inhibited the binding of 13 ligands with
Toyoshi Umezu
doaj +1 more source
Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse [PDF]
, 2018 Alpha-synuclein is the main component of Lewy bodies, a histopathological finding of Parkinson's disease. Prolyl oligopeptidase (PREP) is a serine protease that binds to alpha-synuclein and accelerates its aggregation in vitro.
Julku, Ulrika H. +7 more
core +1 more source
Effect of methylphenidate treatment during adolescence on norepinephrine transporter function in orbitofrontal cortex in a rat model of attention deficit hyperactivity disorder [PDF]
, 2015 Attention deficit hyperactivity disorder (ADHD) is associated with hypofunctional medial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC). Methylphenidate (MPH) remediates ADHD, in part, by inhibiting the norepinephrine transporter (NET). MPH also
Dwoskin, Linda P. +2 more
core +4 more sources