Results 31 to 40 of about 112,056 (332)

Patient Survey on Satisfaction and Impact of 123I-Ioflupane Dopamine Transporter Imaging. [PDF]

PLoS ONE, 2015
Patients were surveyed to assess the impact of dopamine transporter imaging on diagnostic confidence, change in treatment plan, effect on medication compliance, and subjective well-being.
Matthew F Covington, Scott Sherman, Denise Lewis, Hong Lei, Elizabeth Krupinski, Phillip H Kuo   +5 more
doaj   +1 more source

Dopamine Transporter Deficiency Syndrome (DTDS): Expanding the Clinical Phenotype and Precision Medicine Approaches

Cells, 2023
Infantile parkinsonism-dystonia due to dopamine transporter deficiency syndrome (DTDS) is an ultrarare childhood movement disorder caused by biallelic loss-of-function mutations in the SLC6A3 gene.
Joanne Ng, Serena Barral, Simon N. Waddington, Manju A. Kurian   +3 more
doaj   +1 more source

Balanced dopamine is critical for pattern completion during associative memory recall. [PDF]

PLoS ONE, 2010
Pattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the memory process. However, little is known regarding the molecular and cellular mechanisms underlying this process.
Fei Li, L Phillip Wang, Xiaoming Shen, Joe Z Tsien   +3 more
doaj   +1 more source

Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3 [PDF]

, 2016
The mechanisms by which stressful life events increase the risk of relapse in recovering cocaine addicts are not well understood. We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking
A Amphoux, A Schmitt, Analisa Taylor, BA Nic Dhonnchadha, Beliz Kurtoglu, Brittany Nino, D Gründemann, D Gründemann, D Gründemann, DA Baker, David A Baker, DM Platt, E Schomig, EN Graf, F Martel, G Horvath, H Duan, HW Shen, Jayme R McReynolds, JJ Burmeister, JL Malisch, John R Mantsch, JR Mantsch, JR McReynolds, K Engel, LC Daws, LL Iversen, M Aliczki, M Cui, N Baganz, NL Baganz, O Vranjkovic, Oliver Vranjkovic, Olivia Derricks, Paul J Gasser, PJ Fletcher, PJ Gasser, PJ Gasser, R Sinha, R Sinha, R Zwart, Robert A Wheeler, S Erb, S Gong, SZ Langer, T Lenz, T Shang, Terra Ambrosius, V Gorboulev, V Vialou, V Vialou, XY Zhang   +51 more
core   +2 more sources

Dopamine transporters govern diurnal variation in extracellular dopamine tone [PDF]

Proceedings of the National Academy of Sciences, 2014
SignificanceThe mechanism for diurnal (i.e., light/dark) oscillations in extracellular dopamine tone in mesolimbic and nigrostriatal systems is unknown. This is because, unlike other neurotransmitter systems, variation in dopamine tone does not correlate with variation in dopamine cell firing.
Mark J, Ferris, Rodrigo A, España, Jason L, Locke, Joanne K, Konstantopoulos, Jamie H, Rose, Rong, Chen, Sara R, Jones   +6 more
openaire   +2 more sources

What mechanisms are responsible for the reuptake of levodopa-derived dopamine in parkinsonian striatum?

Frontiers in Neuroscience, 2016
Levodopa is the most effective medication for motor symptoms in Parkinson’s disease. However, various motor and non-motor complications are associated with levodopa treatment, resulting from altered levodopa-dopamine metabolism with disease progression ...
Haruo Nishijima, Haruo Nishijima, Masahiko Tomiyama, Masahiko Tomiyama   +3 more
doaj   +1 more source

The dopamine transporter antiports potassium to increase the uptake of dopamine

Nature Communications, 2022
The dopamine transporter, DAT, controls dopamine signaling by facilitating its reuptake using the Na+ gradient as driving force. Here, the authors uncover that an antiport of K+ ions also contributes to setting the rate of DAT-mediated dopamine clearance.
Solveig G. Schmidt, Mette Galsgaard Malle, Anne Kathrine Nielsen, Søren S.-R. Bohr, Ciara F. Pugh, Jeppe C. Nielsen, Ida H. Poulsen, Kasper D. Rand, Nikos S. Hatzakis, Claus J. Loland   +9 more
doaj   +1 more source

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]

, 2014
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
A Garcia-Espana, A Moszczynska, A Priyadarshi, Alexander Holmes, Anton Gartner, AT Allen, B Giros, C Boucheix, C Boucheix, C Boucheix, C Klein, C Missale, CD Dunn, CH Lai, D Vallone, DB Calne, DL Chase, E Rubinstein, E Rubinstein, EA Bolan, ER Sawin, ES Calipari, FJ Lee, FJ Lee, GC Cotzias, GR Uhl, H Maharaj, H Moribe, H Moribe, HP Rang, J Bove, J Sulston, JE Galvin, JG White, JM Beaulieu, JW Langston, K Jellinger, K Strange, K Tieu, KF Tipton, Kim A. Caldwell, L Carvelli, LD Jayanthi, M Santiago, MJ Ferris, MJ LaVoie, MJ Zigmond, ML Toth, MS Szczypka, MW Davis, MY Chang, N Chen, Neda Masoudi, O Thompson, P Seeman, P Seeman, P Sokoloff, Pablo Ibanez-Cruceyra, PW McDonald, QY Zhou, R Andrew, R Nass, R Nass, RM Kostrzewa, RR Gainetdinov, S Brenner, S Cao, S Charrin, S Fahn, S Fahn, S Thaminy, Sarah-Lena Offenburger, TN Chase, W Birkmayer, WA Cass, Y Glinka   +75 more
core   +5 more sources

Reward‐enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention‐deficit/hyperactivity disorder

Neuropsychopharmacology Reports, 2018
Aim Attention‐deficit/hyperactivity disorder is a heterogeneous neurobiological disorder that is characterized by inattention, impulsivity, and an increase in motor activity.
Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R. Uhl, Ichiro Sora, Kazutaka Ikeda   +6 more
doaj   +1 more source

The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging [PDF]

, 2006
Recent data from animal studies raise the possibility that dopaminergic neuromodulation promotes the encoding of novel stimuli. We investigated a possible role for the dopaminergic midbrain in human episodic memory by measuring how polymorphisms in ...
Bernstein, HG, Bunzeck, N, Duzel, E, Fenker, DB, Gundelfinger, ED, Heinze, HJ, Lauer, CJ, Schott, BH, Seidenbecher, CI, Tischmeyer, W   +9 more
core   +1 more source