Results 151 to 160 of about 51,709 (292)

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

Structural basis for pharmacotherapeutic action of triple reuptake inhibitors. [PDF]

Nat Commun
Li Y, Meng Y, Li N, Zhao J, Li R, Bai Q, Wang G, Zhao Y.   +7 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Membrane Dysfunction as a Central Mechanism in LRRK2-Associated Parkinson's Disease: Comparative Analysis of G2019S and I1371V Variants. [PDF]

Cells
Singh K, Banerjee R, Potdar C, Shaw A, Rakshith R, Kamble N, Holla V, Yadav R, Pal PK, Datta I.   +9 more
europepmc   +1 more source

Constructing better electrode–electrolyte interphases in sodium‐ion battery cathodes

InfoMat, EarlyView.
Recent work on the engineering of electrode–electrolyte interphases (EEIs) in sodium‐ion batteries (SIBs) cathode materials has been summarized. The classifications and corresponding problems are presented, followed by electrolyte, auxiliary, and electrode engineering methods.
Junpeng Xie, Zheng Hu, Liang Ma, Jinliang Li, Wenjie Mai   +4 more
wiley   +1 more source

PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models. [PDF]

Brain
Albornoz EA, Mardon K, Bhalla R, Kumar V, Stimson DHR, Cowin G, Cui CS, Butler MS, Pelingon R, Gordon R, Coll RC, Schroder K, Halai R, MacLeod AM, Matthews K, Robertson AAB, Cooper MA, Woodruff TM.   +17 more
europepmc   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, EarlyView.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

MicroRNA-132/212 negatively modulates opioid reward by targeting dopamine transporter in the ventral tegmental area. [PDF]

Transl Psychiatry
Meng J, Li Z, Zhang Y, Zhang D, Liu H, Zang X, Zhao Y, Wen J, Shu W, Nan X, Li X, Xue YX, Jia X.   +12 more
europepmc   +1 more source

Freeze‐resistant, conductive semi‐interpenetrating network hydrogels enable oxidative stress regulation and enhanced wound healing

Interdisciplinary Medicine, EarlyView.
A multifunctional SFMA9/PF1 semi‐interpenetrating hydrogel with excellent conductivity, antioxidant activity, and freeze resistance effectively regulates the wound microenvironment, reduces oxidative stress and inflammation, promotes angiogenesis, and accelerates full‐thickness skin regeneration.
Xiaomin Sun, Yanqin Yu, Xinyuan He, Kaiyi Tang, Lijing Teng, Tianbao Qian, Zhu Zeng, Zuquan Hu   +7 more
wiley   +1 more source

Neurotransmitter Systems in Alzheimer's Disease. [PDF]

Curr Issues Mol Biol
Ramírez-Expósito MJ, Cueto-Ureña C, Martínez-Martos JM.   +2 more
europepmc   +1 more source