Results 181 to 190 of about 835,318 (379)

TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. [PDF]

open access: bronze, 1995
Kerstin Krieglstein   +3 more
openalex   +1 more source

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors

open access: yesNature Neuroscience, 2016
Ada Eban-Rothschild   +4 more
semanticscholar   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

open access: yesMedicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman   +6 more
wiley   +1 more source

Recent Advancements in Microfluidic Biosensors for Clinical Applications

open access: yesiLABMED, EarlyView.
The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management.
Haiyan Wang, Wenjuan Wu
wiley   +1 more source

Reconstitution of the Human Nigro-striatal Pathway on-a-Chip Reveals OPA1-Dependent Mitochondrial Defects and Loss of Dopaminergic Synapses

open access: yesCell Reports, 2019
Summary: Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and ...
Angelo Iannielli   +9 more
doaj  

L-Type Calcium Channels Mediate a Slow Excitatory Synaptic Transmission in Rat Midbrain Dopaminergic Neurons [PDF]

open access: bronze, 1998
Antonello Bonci   +3 more
openalex   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

open access: yesInterdisciplinary Medicine, EarlyView.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma   +10 more
wiley   +1 more source

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