Results 21 to 30 of about 835,318 (379)

Dopaminergic regulation of orexin neurons [PDF]

European Journal of Neuroscience, 2005
AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael, Fadel, Jim R., Jackson, Lela L., Meador-Woodruff, James H., Jing, Deqiang, Deutch, Ariel Y.   +5 more
openaire   +4 more sources

Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice

Molecular Brain, 2020
Aging-related dopaminergic neuronal loss and its motor phenotypes are well known. Excessive loss of dopaminergic neurons leads to Parkinson’s disease (PD), the most common neurodegenerative disorder characterized by the loss of nigrostriatal dopamine ...
Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Nobutaka Hattori   +4 more
doaj   +1 more source

SKP-SCs transplantation alleviates 6-OHDA-induced dopaminergic neuronal injury by modulating autophagy

Cell Death and Disease, 2021
Parkinson’s disease is a common neurodegenerative disease. Cell transplantation is a promising therapeutic option for improving the survival and function of dopaminergic neurons, but the mechanisms underlying the interaction between the transplanted ...
Chengxiao Ma, Wen Zhang, Wengcong Wang, Jiabing Shen, Kefu Cai, Mei Liu, Maohong Cao   +6 more
doaj   +1 more source

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review).

International Journal of Molecular Medicine, 2018
Oxidative stress is increasingly recognized as a central event contributing to the degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD). Although reactive oxygen species (ROS) production is implicated as a causative factor
Ji-dong Guo, Xin Zhao, Yang Li, Guang-Ren Li, Xiao-Liang Liu   +4 more
semanticscholar   +1 more source

Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons [PDF]

Scientific Reports, 2017
AbstractDuring development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. However, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. We previously showed that paired-cultivation of mesencephalic cells containing dopaminergic neurons with striatal ...
Seiko Wakita, Chisato Kanbara, Toshiaki Kume, Yasuhiko Izumi, Akinori Akaike, Akinori Akaike, Toshie Nakai   +6 more
openaire   +3 more sources

Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.

PLoS ONE, 2011
Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhart   +5 more
doaj   +1 more source

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

Cell Death and Disease, 2019
Evolving concepts on Parkinson’s disease (PD) pathology suggest that α-synuclein (aSYN) promote dopaminergic neuron dysfunction and death through accumulating in the mitochondria.
G. Ganjam, K. Bolte, L. Matschke, S. Neitemeier, A. Dolga, M. Höllerhage, G. Höglinger, A. Adamczyk, N. Decher, W. Oertel, C. Culmsee   +10 more
semanticscholar   +1 more source

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. [PDF]

PLoS ONE, 2013
The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia nigra,
Nadia Schendzielorz, Juha-Pekka Oinas, Timo T Myöhänen, Ilkka Reenilä, Atso Raasmaja, Pekka T Männistö   +5 more
doaj   +1 more source

LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Identifying dysfunctional cellular mechanisms in sporadic neurodegenerative diseases has been challenging. Therefore, in-depth investigation of genetic forms of disease can provide valuable insight into pathogenic disease mechanisms.
M. Nguyen, D. Krainc
semanticscholar   +1 more source

Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Parkinson’s disease is characterized by the accumulation of amyloid deposits in dopaminergic neurons, mainly composed of the protein α-synuclein.
Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, F. Pinheiro, Danilo González, Anita Čarija, Susanna Navarro, María Conde-Giménez, Jesús García, S. Guardiola, E. Giralt, X. Salvatella, J. Sancho, M. Sodupe, T. Outeiro, E. Dalfo, S. Ventura   +17 more
semanticscholar   +1 more source