Results 31 to 40 of about 835,318 (379)
How to make a midbrain dopaminergic neuron [PDF]
Development, 2015 ABSTRACT Midbrain dopaminergic (mDA) neuron development has been an intense area of research during recent years. This is due in part to a growing interest in regenerative medicine and the hope that treatment for diseases affecting mDA neurons, such as Parkinson's disease (PD), might be facilitated by a better understanding of how these ...
J. Carlos Villaescusa +4 more
openaire +4 more sources
Brain neurons as quantum computers: {\it in vivo} support of background physics [PDF]
Internatioanl Journal of Modern Physics C: 14, 897-904 (2003), 2003 The question: whether quantum coherent states can sustain decoherence, heating and dissipation over time scales comparable to the dynamical timescales of the brain neurons, is actively discussed in the last years. Positive answer on this question is crucial, in particular, for consideration of brain neurons as quantum computers.
arxiv +1 more source
Automated microfluidic cell culture of stem cell derived dopaminergic neurons
Scientific Reports, 2019 Parkinson’s disease is a slowly progressive neurodegenerative disease characterised by dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the development of human in vitro cellular models of the disease is a major challenge
Khalid I. W. Kane +10 more
semanticscholar +1 more source
Punishment Prediction by Dopaminergic Neurons in Drosophila [PDF]
Current Biology, 2005 The temporal pairing of a neutral stimulus with a reinforcer (reward or punishment) can lead to classical conditioning, a simple form of learning in which the animal assigns a value (positive or negative) to the formerly neutral stimulus. Olfactory classical conditioning in Drosophila is a prime model for the analysis of the molecular and neuronal ...
Erich Buchner +4 more
openaire +3 more sources
npj Parkinson's Disease, 2022 In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as Parkinson’s disease (PD).
Alcmène Chalazonitis +2 more
doaj +1 more source
Exploring Neuronal Bistability at the Depolarization Block [PDF]
(2012) PLoS ONE 7(8): e42811, 2012 Many neurons display bistability - coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in ...
arxiv +1 more source
Cell Death and Disease, 2019 A major hallmark of Parkinson's disease is loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The pathophysiological mechanisms causing this relatively selective neurodegeneration are poorly understood, and thus experimental ...
Sameehan Mahajani +4 more
semanticscholar +1 more source
Spontaneous Activity of Dopaminergic Retinal Neurons [PDF]
Biophysical Journal, 2003 Dopaminergic local circuit neurons in the retina (DA cells) show robust, spontaneous, tetrodotoxin-sensitive pacemaking. To investigate the mechanism underlying this behavior, we characterized the sodium current and a subset of the potassium currents in the cells in voltage-clamp experiments.
Michael A. Steffen +6 more
openaire +3 more sources
Neural Regeneration Research, 2021 Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem cells. However, its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains unclear.
Chao Han +7 more
doaj +1 more source
Dopaminergic neurons write and update memories with cell-type-specific rules
eLife, 2016 Associative learning is thought to involve parallel and distributed mechanisms of memory formation and storage. In Drosophila, the mushroom body (MB) is the major site of associative odor memory formation. Previously we described the anatomy of the adult
Yoshinori Aso, G. Rubin
semanticscholar +1 more source