Results 61 to 70 of about 199,386 (303)
Physiological characterisation of human iPS-derived dopaminergic neurons.
PLoS ONE, 2014 Human induced pluripotent stem cells (hiPSCs) offer the potential to study otherwise inaccessible cell types. Critical to this is the directed differentiation of hiPSCs into functional cell lineages.
Elizabeth M Hartfield +6 more
doaj +1 more source
Frontiers in Neuroanatomy, 2014 Calbindin (CB) is a calcium binding protein reported to protect dopaminergic neurons from degeneration. Although a direct link between CB content and differential vulnerability of dopaminergic neurons has long been accepted, factors other than CB have ...
Iria G Dopeso-Reyes +14 more
doaj +1 more source
Advanced Science, EarlyView.Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren +9 more
wiley +1 more source
Motor skill learning and reward consumption differentially affect VTA activation
Scientific Reports, 2018 Dopamine release from the ventral tegmental area (VTA) terminals in the primary motor cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic VTA neurons projecting to M1 are activated when rewards are obtained during ...
Susan Leemburg +2 more
doaj +1 more source
Stem Cell Research, 2019 Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway.
Dominique Leitner +3 more
doaj +1 more source
Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo. [PDF]
PLoS ONE, 2015 Ciliary neurotrophic factor (CNTF) is one of representative neurotrophic factors for the survival of dopaminergic neurons. Its effects are primarily mediated via CNTF receptor α (CNTFRα).
Kyoung Hoon Jeong +3 more
doaj +1 more source
Four individually identified paired dopamine neurons signal reward in larval Drosophila [PDF]
, 2016 Dopaminergic neurons serve multiple functions, including reinforcement processing during associative learning [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12]. It is thus warranted to understand which dopaminergic neurons mediate which function.
Gerber, Bertram +10 more
core +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
The dopaminergic system in the aging brain of Drosophila
Frontiers in Neuroscience, 2010 Drosophila models of Parkinson’s disease are characterised by two principal phenotypes: the specific loss of dopaminergic neurons in the aging brain and defects in motor behavior.
Katherine E White +2 more
doaj +1 more source
Regenerative Medicine for the Aging Brain [PDF]
, 2014 In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during ...
Goya, Rodolfo Gustavo +3 more
core +2 more sources