Results 61 to 70 of about 835,318 (379)

Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]

The Journal of Neuroscience, 1997
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
Ranjita Betarbet, Allan I. Levey, Robert Turner, Judith R. Walters, Kelly A. Allers, J. Timothy Greenamyre, Vijay Chockkan, Mahlon R. DeLong   +7 more
openaire   +2 more sources

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Nature Communications, 2016
Orexins are associated with drug relapse in rodents. Here, we show that acute restraint stress in mice activates lateral hypothalamic (LH) orexin neurons, increases levels of orexin A and 2-arachidonoylglycerol (2-AG) in the ventral tegmental area (VTA),
Li-Wei Tung, Guan-Ling Lu, Yen‐Hsien Lee, Lung Yu, Hsin-Jung Lee, E. Leishman, H. Bradshaw, L. Hwang, M. Hung, K. Mackie, A. Zimmer, L. Chiou   +11 more
semanticscholar   +1 more source

Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine

Autophagy, 2017
The molecular basis of chronic morphine exposure remains unknown. In this study, we hypothesized that macroautophagy/autophagy of dopaminergic neurons would mediate the alterations of neuronal dendritic morphology and behavioral responses induced by ...
L. Su, Rongcan Luo, Qianjin Liu, Jing-Ran Su, Lu-Xiu Yang, Yu-Qiang Ding, Lin Xu, Yong-Gang Yao   +7 more
semanticscholar   +1 more source

NOX4 exacerbates Parkinson’s disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Research
Parkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin, Changzhou Ying, Xiaoli Si, Naijia Xue, Yi Liu, Ran Zheng, Ying Chen, Jiali Pu, Baorong Zhang   +8 more
doaj   +1 more source

Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats [PDF]

, 2020
For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral subiculum (SUB) is a particular target region for neurodevelopemental disturbances in schizophrenia.
arxiv   +1 more source

Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons

Scientific Reports, 2017
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopaminergic neurons via conditional deletion of ...
W. Choi, Hyung-wook Kim, F. Tronche, R. Palmiter, D. Storm, Z. Xia   +5 more
semanticscholar   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Growth factors and feeder cells promote differentiation of human embryonic stem cell into dopaminergic neurons: a novel role of fibroblast growth factor-20

Frontiers in Neuroscience, 2008
Human embryonic stem cells (hESCs) are a potential source of dopaminergic neurons for treatment of Parkinson’s disease (PD). Dopaminergic neurons can be derived from hESCs and display a characteristic midbrain phenotype. Once transplanted, they can
Ana Sofia Correia, Jia-Yi Li, Patrik Brundin   +2 more
doaj   +1 more source

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Degeneration of midbrain dopamine neurons is the main pathological hallmark of Parkinson’s disease. Identifying transcriptional programs that maintain these neurons in the adult brain will help us understand their specific vulnerability ...
Hélène Doucet-Beaupré, Catherine H Gilbert, Marcos Schaan Profes, Audrey Chabrat, C. Pacelli, N. Giguère, Véronique Rioux, Julien Charest, Q. Deng, A. Laguna, J. Ericson, T. Perlmann, S. Ang, F. Cicchetti, M. Parent, L. Trudeau, M. Lévesque   +16 more
semanticscholar   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, EarlyView.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Seon Yeong Chae, Min Jae Kim, Ki Jun Yu, Hwa Kyoung Shin, Suck Won Hong   +7 more
wiley   +1 more source