Results 81 to 90 of about 4,728 (163)

Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide.

, 1995
Following a single-dose, open-label, pilot pharmacokinetic study in six subjects, the systemic pharmacokinetics and metabolic effects of dorzolamide after topical ocular administration were investigated in a double-blind, randomised, placebo-controlled ...
Jaquet, F., Brunner-Ferber, F., Magnin, J.L., Buclin, T., Biollaz, J., Gervasoni, J.P., Munafo, A.   +6 more
core   +2 more sources

Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma

, 2001
Addition of dorzolamide to timolol in primary open-angle glaucoma shows augmented reduction of intraocular pressure.
Cole, C, Garzozi, H, Jonescu-Cuypers, Christian Paul, Martin, B, Larry Kagemann, Craig Cole, Bruce Martin, Nowacki, E A, Kagemann, L, Alon Harris, Hanna Garzozi, Harris, A, Christian P Jonescu-Cuypers, Elizabeth Anne Nowacki   +13 more
core   +1 more source

Effect of dorzolamide compared with timolol maleate on the central corneal thickness and endothelial-cell count of glaucomatous eyes

Philippine Journal of Ophthalmology, 2007
Objective: This study determined the effect of topical dorzolamide versus timolol on central corneal thickness (CCT) and endothelial cell count of glaucomatous eyes. Methods: A randomized controlled trial was conducted involving 37 eyes of 37 patients
Ernesto D. Golez III, MD, Manuel B. Agulto, MD, Ma. Margarita L. Luna, MD   +2 more
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Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Clostridium perfringens (CpeCA) was recently characterised kinetically and for its anion inhibition profile. In the search of effective CpeCA inhibitors, possibly useful to inhibit
Daniela Vullo, R. Siva Sai Kumar, Andrea Scozzafava, James G. Ferry, Claudiu T. Supuran   +4 more
doaj   +1 more source

Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

, 2010
The goal of glaucoma management is to reduce intraocular pressure (IOP) and maintain it at a level compatible with the health of the optic nerve. New therapies are constantly being sought.
PUGLIESE, Michela, DE MAJO, Massimo, NIUTTA, Pietro Paolo, SCARDILLO A., PUGLIESE, Antonio   +4 more
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Ocular hypotensive effect, preservation of visual fields, and safety of adding dorzolamide to prostaglandin therapy for twelve months

Clinical Ophthalmology, 2011
Kenji Inoue1,3, Mieko Masumoto1,3, Masato Wakakura1, Goji Tomita2, On behalf of the Ochanomizu Ophthalmology Study Group31Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan; 3Ochanomizu ...
Kenji Inoue, Mieko Masumoto, Masato Wakakura, et al   +3 more
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Topical three-drug combination in the management of pseudophakic cystoid macular edema

Journal of Clinical Ophthalmology and Research
The purpose was to report the outcome after usage of three topical eyedrops combination, consisting of one steroid, one carbonic anhydrase inhibitor (CAI), and one non-steroidal anti-inflammatory drug (NSAID) in the treatment of pseudophakic cystoid ...
Siddharth Sane, Prabhushanker Mahalingam, Geetha Ganesan   +2 more
doaj   +1 more source

Rational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucoma

Clinical Ophthalmology, 2008
Jason Yeh1, Daniel Kravitz2, Brian Francis11Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 2Tulane University, School of Medicine, New Orleans, LA, USAAbstract: Glaucoma is a multifactorial optic ...
Jason Yeh, Daniel Kravitz, Brian Francis
doaj  

DEVELOPMENT AND CHARACTERIZATION OF DORZOLAMIDE LOADED NOVASOMES FOR THE MANAGEMENT OF GLAUCOMA [PDF]

A chronic eye condition called glaucoma is characterized by damage to the retinal nerve and progressive vision loss, primarily brought on by high intraocular pressure (IOP). It is one of the main causes of permanent blindness in the world. Currently, the
Sandeep S Pathare, Kazi Mohamad Shayan, Manoj S Tare, Yogyata S Pathare   +3 more
core   +1 more source

Preference for a fixed combination of brinzolamide/timolol versus dorzolamide/ timolol among patients with open-angle glaucoma or ocular hypertension

Clinical Ophthalmology, 2013
Ana Sanseau,1 Juan Sampaolesi,2 Emilio Rintaro Suzuki Jr,3 Joao Franca Lopes,4 Hector Borel51Instituto de la Visión, Ciudad de Buenos Aires, Argentina; 2Consultorio Oftalmologico Sampaolesi, Ciudad de Buenos Aires, Argentina; 3Oftalmoclinica ...
Sanseau A, Sampaolesi J, Suzuki Jr ER, Lopes JF, Borel H   +4 more
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