Results 81 to 90 of about 6,478 (222)

Sulphonamide inhibition studies of the β-carbonic anhydrase from the bacterial pathogen Clostridium perfringens

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
The β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Clostridium perfringens (CpeCA) was recently characterised kinetically and for its anion inhibition profile. In the search of effective CpeCA inhibitors, possibly useful to inhibit
Daniela Vullo, R. Siva Sai Kumar, Andrea Scozzafava, James G. Ferry, Claudiu T. Supuran   +4 more
doaj   +1 more source

Toxicity and Physiological Actions of Carbonic Anhydrase Inhibitors to Aedes aegypti and Drosophila melanogaster

Insects, 2016
The physiological role of carbonic anhydrases in pH and ion regulation is crucial to insect survival. We examined the toxic and neurophysiological effects of five carbonic anhydrase inhibitors (CAIs) against Aedes aegypti.
Sheena A. M. Francis, Jennina Taylor-Wells, Aaron D. Gross, Jeffrey R. Bloomquist   +3 more
doaj   +1 more source

Resolution of bilateral ptosis after reduction of unilaterally elevated intraocular pressure in a child with Axenfeld-Reiger spectrum disorder. [PDF]

, 2012
We report a 9-month-old boy with bilateral pseudoptosis associated with elevated IOP. The patient had previously undergone bilateral trabeculectomies and Ahmed tube placement and right cataract extraction and penetrating keratoplasty.
Levin, Alex V., Soin, Ketki
core   +2 more sources

The Cellular Mechanism for Water Detection in the Mammalian Taste System [PDF]

, 2017
Initiation of drinking behavior relies on both internal state and peripheral water detection. While central neural circuits regulating thirst have been well studied, it is still unclear how mammals recognize external water. Here we show that acid-sensing
AL Huang, AM Rosen, BP Halpern, DA Yarmolinsky, DH Zald, Dhruv Zocchi, DR Evans, EM Stricker, ER Liman, ES Boyden, G Liljestrand, G Nelson, G Nelson, Gunther Wennemuth, H Matsunami, J Chandrashekar, J Chandrashekar, JD Bushman, JF Storm, JM Dessirier, JN Betley, KL Mueller, LH Schneyer, M Yamamoto, MJ McKinley, MJ McKinley, ML Wolbarsht, N Chaudhari, N Shigemura, P Cameron, RB Chang, S Baliga, SB Abbott, SM Sternson, T Hanamori, T Shingai, T Shingai, TE Finger, TE Finger, W Ye, Y Ishimaru, Y Oka, Y Oka, Y Peng, Y Zhang, Yuki Oka   +45 more
core   +2 more sources

The Effect of Dorzolamide Ophthalmic Drops in the Treatment of Patients with Central Serous Chorioretinopathy [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul
Background and Objective: Central Serous Chorioretinopathy (CSCR) is a common retinal disorder. The aim of this study was to evaluate the effectiveness of 2% dorzolamide eye drops in accelerating the recovery from acute CSCR.
R Ebrahimi, A Moradi, B Heydari, Gh Yaghoobi, MA Yaghoubi   +4 more
doaj  

New RP-HPLC Method Development and Validation for Dorzolamide in Ophthalmic Dosage Form

Journal of Analytical Methods in Chemistry, 2018
A reversed phase liquid chromatographic method with UV detection at 254 nm for dorzolamide assay in ophthalmic solutions was developed and validated. Chromatographic separation was achieved on a Zorbax SB C18 (250 mm × 4.6 mm, 5 µm) column kept at 30°C ...
Boovizhikannan Thangabalan, Getu Kahsay, Tadele Eticha   +2 more
doaj   +1 more source

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure. [PDF]

, 2017
PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and
Bonelli, Laura, Caprioli, Joseph, Clark, Robert A, Coleman, Anne L, Demer, Joseph L, Giaconi, JoAnn A, Law, Simon K, Nouri-Mahdavi, Kouros, Suh, Soh Youn   +8 more
core   +1 more source

Patient perspectives when switching from Cosopt® (dorzolamide-timolol) to Azarga™ (brinzolamide-timolol) for glaucoma requiring multiple drug therapy

Clinical Ophthalmology, 2012
Graham Anthony Auger, Mathew Raynor, Simon LongstaffOphthalmology Department, Royal Hallamshire Hospital, Sheffield, South Yorkshire, United KingdomBackground: This study aimed to determine the impact of switching patients requiring multiple drug ...
Auger GA, Raynor M, Longstaff S
doaj  

Efficacy of adjuvant topical timolol–dorzolamide with intravitreal bevacizumab injection in diabetic macular edema: A contralateral eye study

Journal of Current Ophthalmology, 2019
Purpose: To assess the efficacy of adjuvant topical timolol–dorzolamide with intravitreal bevacizumab (IVB) injection on anatomic and functional results in eyes affected with diabetic macular edema (DME).
Ahmad Mirshahi, Ramin Tadayoni, Navid Mohsenzadeh, Talieh Saeidi Rezvani, Mojtaba Abrishami   +4 more
doaj   +1 more source

Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report [PDF]

, 2008
Introduction A case of severe acute bilateral angle closure glaucoma with complete visual loss after oral topiramate therapy. Case presentation A 34 year-old woman developed bilateral severe visual loss 2 days after doubling the dosage of topiramate. Her
Kakarla V Chalam, Tina Tillis, Farhana Syed, Swati Agarwal, Vikram S Brar, JT Banta, J Levy, FW Fraunfelder, JE Craig, FA Medeiros, SD Silberstein, E Eisenberg, P Raskin, N Celebisoy, BA Johnson   +14 more
core   +1 more source