Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses [PDF]
BMC Biology, 2020 Background The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to ...
Katherine E. Larrimore +3 more
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Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes. [PDF]
PLoS Genetics, 2017 Understanding buffering mechanisms for various perturbations is essential for understanding robustness in cellular systems. Protein-level dosage compensation, which arises when changes in gene copy number do not translate linearly into protein level, is ...
Koji Ishikawa +4 more
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X chromosome inactivation across primary human tissues is mostly complete, with significant implications for genetic and clinical studies [PDF]
BMC GenomicsBackground X chromosome inactivation (XCI) refers to silencing of genes on one copy of the X chromosome in XX females, resulting in dosage compensation between XX females and XY males.
Daniel Shriner +8 more
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The Drosophila over compensating males gene genetically inhibits dosage compensation in males. [PDF]
PLoS ONE, 2013 Male Drosophila are monosomic for the X chromosome, but survive due to dosage compensation. They use the Male Specific Lethal (MSL) complex composed of noncoding roX RNA and histone modifying enzymes to hypertranscribe most genes along the X ∼1.6-1.8 ...
Chiat Koo Lim, Richard L Kelley
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Role of X chromosome and dosage-compensation mechanisms in complex trait genetics. [PDF]
Am J Hum GenetAbstractThe X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated. Here, we systematically assessed the relevance of chrX and the effect of its biology on complex traits
Fu Y +4 more
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Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]
Nature CommunicationsIn mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei +5 more
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Dissection of X chromosome dosage compensation for quantitative traits in sheep using different statistical models [PDF]
Scientific ReportsSince males and females have different number of X chromosome, different mechanisms have evolved to equalize dosage of gene products from the X chromosome between XX females and XY males.
Farhad Ghafouri-Kesbi +1 more
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Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans. [PDF]
PLoS GeneticsDosage compensation in Caenorhabditis elegans equalizes X-linked gene expression between XX hermaphrodites and XO males. The process depends on a condensin-containing dosage compensation complex (DCC), which binds the X chromosomes in hermaphrodites to ...
Jessica Trombley +4 more
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MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer
iScience, 2021 Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy.
ManSai Acón +16 more
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Sex-specific embryonic gene expression in species with newly evolved sex chromosomes. [PDF]
PLoS Genetics, 2014 Sex chromosome dosage differences between females and males are a significant form of natural genetic variation in many species. Like many species with chromosomal sex determination, Drosophila females have two X chromosomes, while males have one X and ...
Susan E Lott +4 more
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