Results 11 to 20 of about 39,387 (246)
Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome. [PDF]
PLoS Genetics, 2015 The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic variation on the X ...
Michael Stocks +3 more
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The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. [PDF]
PLoS Biology, 2013 Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are ...
Qi Zhou +5 more
doaj +7 more sources
Identification of chromatin-associated regulators of MSL complex targeting in Drosophila dosage compensation. [PDF]
PLoS Genetics, 2012 Sex chromosome dosage compensation in Drosophila provides a model for understanding how chromatin organization can modulate coordinate gene regulation. Male Drosophila increase the transcript levels of genes on the single male X approximately two-fold to
Erica Larschan +9 more
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Genetic compensation: A phenomenon in search of mechanisms. [PDF]
PLoS Genetics, 2017 Several recent studies in a number of model systems including zebrafish, Arabidopsis, and mouse have revealed phenotypic differences between knockouts (i.e., mutants) and knockdowns (e.g., antisense-treated animals).
Mohamed A El-Brolosy +1 more
doaj +1 more source
Genetic dosage compensation in a family with velo‐cardio‐facial/DiGeorge/22q11.2 deletion syndrome [PDF]
American Journal of Medical Genetics Part A, 2011 AbstractCytogenetic studies of a male child carrying the 22q11.2 deletion common in patients with velo‐cardio‐facial/DiGeorge syndrome showed an unexpected rearrangement of the 22q11.2 region in his normal appearing mother. The mother carried a 3 Mb deletion on one copy and a reciprocal, similar sized duplication on the other copy of chromosome 22q11.2
Avishai A. Alkalay +6 more
openaire +2 more sources
Computational and Structural Biotechnology Journal, 2020 Hereditary diseases and complex traits often manifest in specific tissues, whereas their causal genes are expressed in many tissues that remain unaffected.
Juman Jubran +3 more
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Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.
PLoS Genetics, 2023 The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid ...
Ana Catalán +3 more
doaj +1 more source
The status of dosage compensation in the multiple X chromosomes of the platypus. [PDF]
PLoS Genetics, 2008 Dosage compensation has been thought to be a ubiquitous property of sex chromosomes that are represented differently in males and females. The expression of most X-borne genes is equalized between XX females and XY males in therian mammals (marsupials ...
Janine E Deakin +3 more
doaj +1 more source
A General Mechanism for Network-Dosage Compensation in Gene Circuits [PDF]
, 2010 Coping with variations in network dosage is crucial for maintaining optimal function in gene networks. We explored how network structure facilitates network-level dosage compensation.
Acar, Murat +4 more
core +2 more sources
PLoS Genetics, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Koji Ishikawa +2 more
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