Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation [PDF]
Genetics, 2010 Abstract Several recent studies have suggested that F1 hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome.
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Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly. [PDF]
PLoS ONE, 2015 In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked ...
Rebecca J Linger +2 more
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Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder. [PDF]
, 2006 The DSM-III, DSM-IV, DSM-IV-TR and ICD-10 have judiciously minimized discussion of etiologies to distance clinical psychiatry from Freudian psychoanalysis.
Bracha, Dr. H. Stefan
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Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster.
PLoS Genetics, 2016 Deletions, commonly referred to as deficiencies by Drosophila geneticists, are valuable tools for mapping genes and for genetic pathway discovery via dose-dependent suppressor and enhancer screens.
Hangnoh Lee +10 more
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THE NATURE OF QUANTITATIVE GENETIC VARIATION IN DROSOPHILA. III. MECHANISM OF DOSAGE COMPENSATION FOR SEX-LINKED ABDOMINAL BRISTLE POLYGENES [PDF]
Genetics, 1977 ABSTRACT Seventeen lines, each homozygous for a different × chromosome but all with a common autosomal genetic background, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character.—The regression coefficient of male mean on female mean using ...
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Abnormal Action Potentials Associated with the Shaker Complex Locus of Drosophila [PDF]
, 1981 Intracellular recordings of action potentials were made from the cervical giant axon in Shaker (Sh) mutants and normal Drosophila. The mutants showed abnormally long delays in repolarization.
Ferrus, Alberto +2 more
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Sex Bias and Maternal Contribution to Gene Expression Divergence in Drosophila Blastoderm Embryos. [PDF]
PLoS Genetics, 2015 Early embryogenesis is a unique developmental stage where genetic control of development is handed off from mother to zygote. Yet the contribution of this transition to the evolution of gene expression is poorly understood.
Mathilde Paris +3 more
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Absence of a Faster-X Effect in Beetles (Tribolium, Coleoptera)
G3: Genes, Genomes, Genetics, 2020 The faster-X effect, namely the rapid evolution of protein-coding genes on the X chromosome, has been widely reported in metazoans. However, the prevalence of this phenomenon across diverse systems and its potential causes remain largely unresolved ...
Carrie A. Whittle +2 more
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Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. [PDF]
, 2007 Many genes can be deleted with little phenotypic consequences. By what mechanism and to what extent the presence of duplicate genes in the genome contributes to this robustness against deletions has been the subject of considerable interest.
Collins, Sean R +4 more
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G3: Genes, Genomes, Genetics, 2016 Theory makes several predictions concerning differences in genetic variation between the X chromosome and the autosomes due to male X hemizygosity. The X chromosome should: (i) typically show relatively less standing genetic variation than the autosomes,
Robert M. Griffin +2 more
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