Results 31 to 40 of about 1,266,466 (336)

Model Selection versus Model Averaging in Dose Finding Studies [PDF]

, 2015
Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug.
Bornkamp, Björn, Bretz, Frank, Dette, Holger, Schorning, Kirsten   +3 more
core   +2 more sources

Initial Approach to the Cellular Irradiation Injury of Human Pancreatic Carcinoma Cell Line MIA PaCa-2 by High Dose per Fraction

Cancer Biology & Medicine, 2010
OBJECTIVE To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. METHODS Human pancreatic carcinoma cell line MIA PaCa-2, was cultivated and divided into 5 groups: 0, 2, 5, 10, 17 ...
Ping WANG, Hai-li YU, Zhi-yong YUAN, Zhi-zhen WANG   +3 more
doaj   +1 more source

Effects of Aerobic and Speed Training Versus Active Control on Repeated Sprint Ability and Measures of Self-confidence and Anxiety in Highly Trained Male Soccer Players

Sports Medicine - Open, 2023
Background While there is ample evidence on the effects of single-mode aerobic and speed training on physical fitness in soccer players, less is known on the combined effects of these exercise regimens on physical and psychological factors.
Walid Selmi, Raouf Hammami, Sofien Kasmi, Sonia Sehli, Haithem Rebai, Michael Duncan, Mokhtar Chtara, Urs Granacher   +7 more
doaj   +1 more source

The relationship between zinc intake and serum/plasma zinc concentration in adults: a systematic review and dose–response meta-analysis by the EURRECA Network [PDF]

, 2012
Dietary zinc recommendations vary widely across Europe due to the heterogeneity of pproaches used by expert panels. Under the EURRECA consortium a protocol was designed to systematically review and undertake meta-analyses of research data to create a ...
Anna-Louise Stammers, Carla Dullemeijer, Higgins, Lluis Serra-Majem, Mariela Nissensohn, Marisol Warthon Medina, Nicola M. Lowe, Olga W. Souverein, Sujata Patel, Victoria Hall Moran   +9 more
core   +2 more sources

A Review of the Dose Justification of Phase 3 Trials to Regulatory Authorities for Drugs Intended for the Treatment of Type 2 Diabetes in Europe

Frontiers in Pharmacology, 2021
Aims: Cardiovascular outcome trials with anti-diabetic drugs suggest that additional cardiovascular benefit can be achieved independent of improving glycaemic control.
Jeroen V. Koomen, Jeroen V. Koomen, Jasper Stevens, Margje H. Monster-Simons, Margje H. Monster-Simons, Hiddo J. L. Heerspink, Peter G. M. Mol, Peter G. M. Mol   +7 more
doaj   +1 more source

The association between perceived stress and mortality among people with multimorbidity: a prospective population-based cohort study [PDF]

, 2016
Multimorbidity is common and is associated with poor mental health and high mortality. Nevertheless, no studies have evaluated whether mental health may affect the survival of people with multimorbidity.
Christensen, Kaj Sparle, Fenger-Grøn, Morten, Larsen, Finn Breinholt, Larsen, Karen Kjær, Mercer, Stewart W., Nielsen, Marie Germund, Prior, Anders, Robinson, Kirstine Magtengaard, Vestergaard, Mogens   +8 more
core   +1 more source

Preclinical Evaluation of Botulinum Toxin Type E (TrenibotulinumtoxinE) Using the Mouse Digit Abduction Score (DAS) Assay

Toxins
TrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson, David Canty, Annemarie Southern, Kevin Whelan, Amy D. Brideau-Andersen, Ron S. Broide   +5 more
doaj   +1 more source

Sugammadex ED90 dose to reverse the rocuronium neuromuscular blockade in obese patients

Revista do Colégio Brasileiro de Cirurgiões
Objective: to determine the ED90 (minimum effective dose in 90% of patients) of sugammadex for the reversal of rocuronium-induced moderate neuromuscular blockade (NMB) in patients with grade III obesity undergoing bariatric surgery.
MAURO PRADO DA SILVA, CHRISTIANO MATSUI, DANIEL DONGIOU KIM, JOAQUIM EDSON VIEIRA, CARLOS ALBERTO MALHEIROS, LIGIA ANDRADE SILVA TELLES MATHIAS   +5 more
doaj   +1 more source

Association between dietary magnesium intake and risk of hypertension in Chinese adults

环境与职业医学, 2022
BackgroundMagnesium plays an important physiological role in human, but the association between dietary magnesium intake and the risk of hypertension is unclear. Few studies have reported the dose-response relationship in Chinese population.
Liusen WANG, Huijun WANG, Zhihong WANG, Hongru JIANG, Weiyi LI, Shaoshunzi WANG, Lixin HAO, Bing ZHANG, Gangqiang DING   +8 more
doaj   +1 more source

Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules

, 2020
Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis.
Friede, Tim, Günhan, Burak Kürsad, Meyvisch, Paul   +2 more
core   +1 more source