Results 41 to 50 of about 1,266,466 (336)

Systematic evaluation of pembrolizumab dosing in patients with advanced non-small cell lung cancer [PDF]

, 2016
International audienceBACKGROUND: In the phase I KEYNOTE-001 study, pembrolizumab demonstrated durable antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). We sought to characterize the relationship between pembrolizumab dose,
Ahamadi, M., Arkenau, H.-T., Cappuzzo, F., Chatterjee, M., De Alwis, D. P., Dong, D., Felip, E., Fløtten, Ø, Freshwater, T., Garon, E. B., Gubens, M. A., Hellmann, M. D., Horn, L., Hui, R., Im, E., Kondic, A. G., Lena, H., Li, C., Lubiniecki, G. M., Mayawala, K., Stone, J., Turner, D. C., Zhang, J.   +22 more
core   +2 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Beyond two-stage models for lung carcinogenesis in the Mayak workers: Implications for Plutonium risk

, 2015
Mechanistic multi-stage models are used to analyze lung-cancer mortality after Plutonium exposure in the Mayak-workers cohort, with follow-up until 2008.
Eidemüller, Markus, Sokolnikov, Mikhail E., Zöllner, Sascha   +2 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Radiation exposure during neurointerventional procedures in modern angiographic systems: A single center experience [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Interventional neuroradiology procedures expose patients to ionizing radiation. The aim of this study was to assess doses received by patients during interventional neuroradiology procedures and to establish dose range with an estimate of
Lukić Snežana, Rasulić Lukas, Kovačević Vojin, Vitošević Filip, Savić Andrija, Mijailović Milan   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. [PDF]

, 2019
During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue.
Astete, Helvio, Halsey, Eric S, Kitron, Uriel, Kochel, Tadeuz J, Morrison, Amy C, Perkins, T Alex, Reiner, Robert C, Scott, Thomas W, Sihuincha, Moises, Smith, David L, Stancil, Jeffrey D, Stoddard, Steven T, Vazquez-Prokopec, Gonzalo M   +12 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity [PDF]

, 2017
BACKGROUND: It is important to quantify the dose response for a drug in phase 2a clinical trials so the optimal doses can then be selected for subsequent late phase trials.
AE Raftery, EH Choy, EJ Calabrese, F Behrens, Feng Liu, J Arrowsmith, J Fransen, J Heydari, K Almstrup, M Hay, MK Smith, N Thomas, P Brain, SC Owen, Stephen J. Walters, Steven A. Julious, W Stohl, Z Skrivanek   +17 more
core   +2 more sources

Dose–Response Relationship Between BMI and Hyperuricemia

International Journal of General Medicine, 2021
Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection,
Yang L, He Z, Gu X, Cheng H, Li L
doaj