Results 51 to 60 of about 2,454,279 (380)
Shrinkage estimation for dose-response modeling in phase II trials with multiple schedules
, 2020 Recently, phase II trials with multiple schedules (frequency of administrations) have become more popular, for instance in the development of treatments for atopic dermatitis.
Friede, Tim +2 more
core +1 more source
The association between perceived stress and mortality among people with multimorbidity: a prospective population-based cohort study [PDF]
, 2016 Multimorbidity is common and is associated with poor mental health and high mortality. Nevertheless, no studies have evaluated whether mental health may affect the survival of people with multimorbidity.
Christensen, Kaj Sparle +8 more
core +1 more source
Nutrients, 2016 The epidemiological evidence for a dose-response relationship between magnesium intake and risk of type 2 diabetes mellitus (T2D) is sparse. The aim of the study was to summarize the evidence for the association of dietary magnesium intake with risk of ...
X. Fang +8 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Complementary Therapies in MedicineObjective: To consolidate and analyze the existing evidence on the relationship between acupuncture treatment frequency and its clinical efficacy, clarify research status, trends, and core issues, and provide evidence-based insights for optimizing ...
Guodong Li +7 more
doaj +1 more source
Dose-Response Relationships for Carcinogens: A Review [PDF]
Environmental Health Perspectives, 1987 We review the experimental evidence for various shapes of dose-response relationships for carcinogens and summarize those experiments that give the most information on relatively low doses. A brief review of some models is given to illustrate the shapes of dose-response curve expected from them.
L, Zeise, R, Wilson, E A, Crouch
openaire +3 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Systematic evaluation of pembrolizumab dosing in patients with advanced non-small cell lung cancer [PDF]
, 2016 International audienceBACKGROUND: In the phase I KEYNOTE-001 study, pembrolizumab demonstrated durable antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). We sought to characterize the relationship between pembrolizumab dose,
Ahamadi, M. +22 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Association between dietary magnesium intake and risk of hypertension in Chinese adults
环境与职业医学, 2022 BackgroundMagnesium plays an important physiological role in human, but the association between dietary magnesium intake and the risk of hypertension is unclear. Few studies have reported the dose-response relationship in Chinese population.
Liusen WANG +8 more
doaj +1 more source