Results 61 to 70 of about 1,339,184 (328)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Comparative effective dose of ciprofol and propofol in suppressing cardiovascular responses to tracheal intubation

Scientific Reports
Ciprofol, a novel γ-aminobutyric acid receptor agonist, outperforms propofol with minimal cardiovascular effects, higher potency, reduced injection pain, and a broader safety margin.
Min Liao, Xiao-Ru Wu, Jia-Ning Hu, Xing-Zhou Lin, Tang‑yuan‑meng Zhao, Hu Sun   +5 more
doaj   +1 more source

Investigating A Dose Response Relationship between High Fat Diet Consumption and the Contractile Performance of Isolated Mouse Soleus, EDL and Diaphragm Muscles [PDF]

, 2019
PurposeRecent evidence has demonstrated an obesity-induced, skeletal muscle-specific reduction in contractile performance. The extent and magnitude of these changes in relation to total dose of high-fat diet consumption remains unclear.
A Abdelmoula, A Matsakas, A Wronska, BH Goodpaster, C Barclay, C Barclay, Cameron Hill, CJ Blimkie, CJ Tanner, D Akhmedov, D Pette, D Tomlinson, DM D’Souza, DS Ward, F Zurlo, FR Paolillo, H Eshima, J Aucouturier, J Ciapaite, J Kemp, J Machann, J Mendez, J Szymura, J Tallis, J Tallis, J Tallis, J Tallis, J Tallis, J Wilde de, Jason Tallis, JD Altringham, JD Bruton, Josh Hurst, KE Shortreed, KE Trajcevski, M Hulens, MA Brotto, MM Thomas, MS Denies, N Miyatake, NA Maffiuletti, NA Maffiuletti, P Capodaglio, P Kopelman, P Rogers, R Singh, RK Josephson, RK Josephson, Rob S. James, RS James, RS James, RS James, S Warmington, SR Anderson, Val M. Cox, Y Rolland, Y Yoshida   +56 more
core   +1 more source

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats [PDF]

, 2021
Tomoki Takeda, Shotaro Yamano, Yuko Goto, Shigeyuki Hirai, Yusuke Furukawa, Yoshinori Kikuchi, Kyohei Misumi, Masaaki Suzuki, Kenji Takanobu, Hideki Senoh, Misae Saito, Hitomi Kondo, George Daghlian, Young‐Kwon Hong, Yasuhiro Yoshimatsu, Masanori Hirashima, Yoichiro Kobashi, Kenzo Okamoto, Takumi Kishimoto, Yumi Umeda   +19 more
openalex   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Dose–Response Relationship Between BMI and Hyperuricemia

International Journal of General Medicine, 2021
Lu Yang,1 Zhen’an He,2 Xuan Gu,3 Hao Cheng,4 Lin Li5 1Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital City, Hangzhou, Zhejiang Province, People’s Republic of China; 2Shaanxi Institute of Medical Device Quality Supervision and Inspection,
Yang L, He Z, Gu X, Cheng H, Li L
doaj  

A Nonparametric Method for the Derivation of α/β Ratios from the Effect of Fractionated Irradiations [PDF]

, 1991
Multifractionation isoeffect data are commonly analysed under the assumption that cell survival determines the observed tissue or tumour response, and that it follows a linear-quadratic dose dependence.
A.M. Kellerer, D. Chmelevsky, Douglas B.G., Douglas B.G., Efron B, Efron B, Guttenberger R., Han A.K, Henkelman R.M., J. Kummermehr, Kellerer A.M., Kummermehr J., Lam G.K.Y., Maciejewski B., R. Guttenberger, Taylor J.M.G., Thames H.D, Tucker S.L, Vegesna V., Williams M.V.   +19 more
core   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. [PDF]

, 2019
During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue.
Astete, Helvio, Halsey, Eric S, Kitron, Uriel, Kochel, Tadeuz J, Morrison, Amy C, Perkins, T Alex, Reiner, Robert C, Scott, Thomas W, Sihuincha, Moises, Smith, David L, Stancil, Jeffrey D, Stoddard, Steven T, Vazquez-Prokopec, Gonzalo M   +12 more
core   +2 more sources