Dose-Response Relationship in Aminonucleoside Nephrosis.
Experimental Biology and Medicine, 1963 SummaryAdministration of 1–3 mg of PA subcutaneously to normal rats at intervals of 1–2 weeks produced significant proteinuria after a prolonged latent period provided the total dose exceeded a threshold dose of approximately 4–5 mg. Analysis of the cumulative dose-response curves revealed that doses administered subcutaneously at biweekly intervals ...
C S, ALEXANDER, V R, HUNT, H T, NAGASAWA
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Association between exposure to noise and risk of hypertension: A meta-analysis of observational epidemiological studies [PDF]
, 2017 Background and Objective: An increasing amount of original studies suggested that exposure to noise could be associated with the risk of hypertension, but the results remain inconsistent and inconclusive.
Cao, Shiyi +9 more
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Retraction and republication—Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses [PDF]
, 2023 The Editors of The Lancet Diabetes Endocrinology
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Frontiers in PhysiologyBackgroundTo compare the effects of various exercise modalities on intelligence and determine the optimal exercise dose for children and adolescents.MethodsA systematic review and Bayesian network meta-analysis following PRISMA guidelines was conducted ...
Yan Wang +9 more
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Thoracic Cancer, 2023 Background Betel nut chewing involves the chewing of areca nuts or betel quid (areca nuts wrapped in betel leaves), which is associated with an increased risk of esophageal squamous cell carcinoma (ESCC). Statins have anticancer properties.
Chih‐Lang Lin +3 more
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Test Of Homogeneity For Umbrella Alternatives In Dose-Response Relationship For Poisson Variables [PDF]
, 2003 This article concerns the testing and estimation of a dose-response effect in medical studies. We study the statistical test of homogeneity against umbrella alternatives in a sequence of Poisson distributions associated with an ordered dose variable.
Ji, Ming, Xiong, Chengjie, Yan, Yan
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Dose-Response Relationship between Training Load and Changes in Aerobic Fitness in Professional Youth Soccer Players [PDF]
, 2018 Purpose: The aim of this study was to compare the dose-response relationship between, traditional arbitrary speed thresholds versus an individualised approach, with changes in aerobic fitness in professional youth soccer players.
Fitzpatrick, John +2 more
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