Results 111 to 120 of about 395,390 (239)

Single‐Layer Radially Compartmentalized Paper Chip (RCP‐Chip) for Rapid Isothermal Multiplex Detection of SARS‐CoV‐2 Gene Targets

Advanced Sensor Research, EarlyView.
The single‐layer RCP‐Chip enables rapid, multiplexed detection of SARS‐CoV‐2 RNA using RT‐LAMP and gold nanoparticle‐enhanced colorimetric readouts. After sample loading, amplification occurs within radially arranged chambers, allowing simultaneous detection of E and N genes.
Pavithra Sukumar, Alla Saleh, Muhammedin Deliorman, Mohammad A. Qasaimeh   +3 more
wiley   +1 more source

Double-stranded RNA prevents and cures infection by rust fungi. [PDF]

Commun Biol, 2023
Degnan RM, Shuey LS, Radford-Smith J, Gardiner DM, Carroll BJ, Mitter N, McTaggart AR, Sawyer A.   +7 more
europepmc   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

Advanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe, Jacobus Burger, Jamie Jones, Apurva Panjla, William L. Murphy   +4 more
wiley   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Action of dimeric ribonucleases on double‐stranded RNA [PDF]

FEBS Letters, 1972
S. Zofra, M. Libonati, Giuseppe D'Alessio   +2 more
openaire   +2 more sources

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Lipid Droplet‐Derived Biomimetic Nanocarriers for the Enhancement of Porcine Intermuscular Fat Content

Advanced Science, EarlyView.
The article presents the development of artificial lipid droplets (aLDs) as biomimetic nanocarriers to enhance intramuscular fat (IMF) content in pigs. These aLDs, loaded with oleic acid, significantly increase IMF by up to 35% in muscle tissues without adverse side effects. This innovative approach improves pork quality by enhancing marbling, offering
Pengxiang Zhao, Hongbo Han, Jingjie Hao, Ziwei Yu, Zichen Zhao, Lupeng Chen, Heng Wang, Jian Wu, Zhuqing Ren   +8 more
wiley   +1 more source

Effective recognition of double-stranded RNA does not require activation of cellular inflammation. [PDF]

Sci Adv
Drazkowska K, Cieslicka J, Kitowicz M, Pastucha A, Markiewicz L, Szymanek W, Goryca K, Kowalczyk T, Cysewski D, Bausch AR, Sikorski PJ.   +10 more
europepmc   +1 more source

Stereotyped Subclones Revealed by High‐Density Single‐Cell Lineage Tracing Support Robust Development

Advanced Science, EarlyView.
Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Xingxing He, Peng Wu, Feng Chen, Ziwei Zhou, Chenze Ren, Yuyan Shan, Xiewen Wen, Vassily A. Lyubetsky, Leonid Yu. Rusin, Xiaoshu Chen, Jian‐Rong Yang   +14 more
wiley   +1 more source