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Amino acid storage: lysosomal double role in health and disease

open access: yesAutophagy Reports
Cellular homeostasis depends on a multitude of cellular functions, which in turn depend on the clearance of damaged components for their maintenance.
Aiswarya Raj   +2 more
doaj   +3 more sources

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid [PDF]

open access: yesNature Communications, 2017
Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the
Youngzee Song   +10 more
doaj   +3 more sources

Leucyl-tRNA synthetase: double duty in amino acid sensing [PDF]

open access: yesCell Research, 2012
The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.
Durán, R. V., Hall, M. N.
openaire   +4 more sources

Impacts of Different Long-Term Fertilizer Management Regimes on Soil Nitrogen Mineralization and Its Enzyme Activities under a Double-Cropping Rice System in Southern China

open access: yesAgronomy, 2023
Soil extracellular enzyme activities play an important role in regulating the soil nitrogen (N) mineralization process in paddy fields. However, there is still a need to further study how N mineralization responds to different fertilizer management ...
Haiming Tang   +6 more
doaj   +1 more source

Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility

open access: yesFrontiers in Microbiology, 2021
Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural analogs either of
Karolina Subko   +10 more
doaj   +1 more source

Facile and Scalable Route to Access Rare Deoxy Amino Sugars for Nonulosonic Acid Aldolase Biosynthesis

open access: yesFrontiers in Chemistry, 2022
We presented a facile and scalable route for the synthesis of di-azido sugars via one-pot double inversion of the mono-benzoyl sugars by TBAN3 and studied the dependency pattern between solvent and protecting groups as well as the configuration of the ...
Yixuan Zhou   +3 more
doaj   +1 more source

Chiral Recognition by DNA-Immobilized TLC Plate

open access: yesSeparations, 2017
DNA-immobilized silica gel TLC plate (DNA-TLC plate) by coating a mixture of double-stranded DNA and silica gel on a glass plate was stable in common organic solvents, such as alcohol, acetone, chloroform, and ethyl acetate.
Masanori Yamada, Mami Inoue
doaj   +1 more source

Erratum: Leucyl-tRNA synthetase: double duty in amino acid sensing [PDF]

open access: yesCell Research, 2012
Due to a production error by the editorial office, this Research Highlight, which was originally published in the August issue of Cell Research (22:1207-1209. doi:10.1038/cr.2012.68; published online 24 April 2012), was inadvertently duplicated in the September issue (22:1312-1314).
Raúl V Durán, Michael N Hall
openaire   +1 more source

Effect of exogenous application of amino acids on fruit quality and productivity of peach (Prunus persica)

open access: yesThe Indian Journal of Agricultural Sciences, 2019
The present investigations were carried out at Fruit Research Farm, Punjab Agricultural University, Ludhiana during 2016-17 to study the effect of exogenous application of amino acids (Peptone) on fruit quality, maturity and productivity of peach (Prunus
MANJOT KAUR   +2 more
doaj   +1 more source

Variations in Total Protein and Amino Acids in the Sequenced Sorghum Mutant Library

open access: yesPlants, 2023
Sorghum (Sorghum bicolor) is the fifth most important cereal crop worldwide; however, its utilization in food products can be limited due to reduced nutritional quality related to amino acid composition and protein digestibility in cooked products.
Adil Khan   +5 more
doaj   +1 more source

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