Results 141 to 150 of about 378,928 (303)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1

, 2012
Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. The present study was undertaken to examine the effects of ciprofloxacin, a fluoroquinolone antibiotic implicated in matrix remodeling, on dermal and lung fibroblasts ...
Padilla, Cristina, Christmann, Romy B., Lafyatis, Robert, Bujor, Andreea M., Sampaio-Barros, Percival D., Junie, Monica, Trojanowska, Maria, Haines, Paul   +7 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MAD2 downregulation in hypoxia is independent of promoter hypermethylation

, 2010
Aberrant expression of the MAD2 protein has been linked to chromosomal instability, malignant transformation and chemoresistance. Although reduced MAD2 expression is well recognised in human cancer cell lines, the mechanism(s) underlying its ...
Fitzpatrick, Patricia, Sine Phelan, Jenny A Watson, McGoldrick, Aloysius, Phelan, Sine, Fiona Furlong, McCann, Amanda, Maria Prencipe, Perry, Antoinette S, Mark Lawler, Kay, Elaine, Aloysius McGoldrick, Antoinette S Perry, Patricia Fitzpatrick, Furlong, Fiona; id_orcid, Anthony O’Grady, Watson, Jenny A, Amanda McCann, Prencipe, Maria, Donal J Brennan, Elaine Kay, Lawler, Mark, McGrogan, Barbara, O'Grady, Anthony, Barbara McGrogan, Brennan, Donal J   +25 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Global Differential Gene Expression In Hypoxic Hepg2 Upon Sirtuin-1 Upregulation And Downregulation [PDF]

Hepatocellular carcinoma (hcc) is one of the leading causes of cancer death worldwide, largely due to its poor prognosis and the emergence of chemoresistance, particularly exacerbated by the hypoxic tumor microenvironment (tme).
Zulkifli, Nur Diyana
core  

Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation

, 2013
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is preferentially cytotoxic to cancer cells over normal cells. However, many cancer cells, including malignant glioma cells, tend to be resistant to TRAIL.
Lee, JA, Mi Jin Yoon, Kim, In Young, Kang, You Jung, Kim, IY, Choi, KS, Jun Hee Lim, Choi, Kyeong Sook, Lim, Jun Hee, Eun Hee Kim, Yoon, MJ, Ju Ahn Lee, Taeg Kyu Kwon, Kyeong Sook Choi, Lee, Ju Ahn, Kim, EH, Yoon, Mi Jin, Lim, JH, Kim, Eun Hee, You Jung Kang, Kwon, Taeg Kyu, Kwon, TK, In Young Kim, Kang, YJ   +23 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Mucosal gastrin receptor. VII. Up- and downregulation

, 1982
A series of experiments were performed to examine the long-term upregulation of the gastrin receptor and to explore the possibility of a short-term down regulation with regard to the time course of the trophic action of gastrin.
L. R. Johnson, G. R. Speir, W. Peitsch, K. Takeuchi   +3 more
core   +1 more source