Results 131 to 140 of about 378,928 (303)

Preferential upregulation of ATP-dependent chaperones in group 1 cancers.

, 2018
Analysis of differential cancer gene expression of chaperome functional subsets. A. Comparing upregulation and downregulation of gene expression (∆GSA) of chaperones (n = 88) and co-chaperones (n = 244) reveals general chaperome upregulation for the ...
Ali Hadizadeh Esfahani (4731474), Andreas A. Schuppert (4731480), Angelina Sverchkova (4731471), Julio Saez-Rodriguez (25229), Marc Brehme (4731477)   +4 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio
The fusion of human serum albumin with human lactoferrin (hLF‐HSA) exerts strong anti‐migratory effects in human lung adenocarcinoma cells through matrix metalloproteinase 1 (MMP1) downregulation.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
doaj   +1 more source

A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML

Molecular Cancer, 2019
Ectopic Viral Integration site 1 (EVI1) upregulation is implicated in 10–25% of pediatric acute myeloid leukemia (AML) and has an inferior outcome with current chemotherapy regimens. Here we report that EVI1 upregulation is associated with methylation of
Nupur Mittal, Liping Li, Yue Sheng, Chao Hu, Fuxing Li, Tongyu Zhu, Xiaohong Qiao, Zhijian Qian   +7 more
doaj   +1 more source

LncRNA WT1-AS Downregulates Survivin by Upregulating miR-203 in Papillary Thyroid Carcinoma.

Cancer management and research, 2020
This study aimed to assessment the functions of lncRNA WT1-AS in papillary thyroid carcinoma (PTC).Expression levels of WT1-AS in PTC and non-tumor tissues from 66 PTC patients were measured and compared by performing qPCR and paired t test, respectively.
Le,Fei, Luo,Ping, Ouyang,Qian, Zhong,Xiaoming   +3 more
openaire   +4 more sources

Irradiation leads to sensitization of hepatocytes to TNF-α-mediated apoptosis by upregulation of IκB expression

, 2009
This study aimed to reveal the pathophysiological signalling responsible for radiation-induced sensitization of hepatocytes to TNF-alpha-mediated apoptosis. I kappa B was upregulated in irradiated hepatocytes.
Ramadori, Giuliano, Christiansen, Hans, Hakan Gürleyen, Bernhard Saile, Tello, Khodr, Hess, Clemens Friedrich, Rave-Fraenk, Margret, Joszef Dudas, Hans Christiansen, Khodr Tello, Giuliano Ramadori, Guerleyen, Hakan, Robert M. Hermann, Clemens F. Hess, Margret Rave-Fränk, Saile, Bernhard, Dudas, Joszef, Hermann, Robert Michael   +17 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Downregulated SIRT6 and upregulated NMNAT2 are associated with the presence, depth and stage of colorectal cancer

Oncology Letters, 2018
Colorectal cancer (CRC) is an important cause of morbidity and mortality worldwide, and is difficult to detect in its early stages. Diagnostic and prognostic biomarkers are required, which may also be the basis for improving the targeted therapy for CRC.
Qi, Jia, Cui, Chunhui, Deng, Quanwen, Wang, Lifeng, Chen, Rihong, Zhai, Duanyang, Xie, Lang, Yu, Jinlong   +7 more
openaire   +3 more sources

MiR-424/503-mediated Rictor upregulation promotes tumor progression.

, 2013
mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive.
Rei Asai, Daisuke Okuzaki, Satoshi Inoue (221875), Rie Kokuda, Kyoko Kakumoto, Jun-ichiro Ikeda, Ken-ichi Takayama (482421), Chitose Oneyama, Ken-ichi Takayama, Yoriko Kito (482414), Eiichi Morii (162029), Masato Okada (189456), Takuya Yoshida, Jun-ichiro Ikeda (482416), Yoriko Kito, Eiichi Morii, Rie Kokuda (482419), Satoshi Inoue, Kyoko Kakumoto (482420), Masato Okada, Chitose Oneyama (482413), Rei Asai (482415), Takuya Yoshida (482417), Daisuke Okuzaki (482418)   +23 more
core   +1 more source