Results 121 to 130 of about 378,928 (303)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Downregulated suppression to obtain upregulated reprogramming [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2018
Mennander Ari A., Mennander Ari
openaire   +2 more sources

Proteomics Reveal a Concerted Upregulation of Methionine Metabolic Pathway Enzymes, and Downregulation of Carbonic Anhydrase-III, in Betaine Supplemented Ethanol-Fed Rats [PDF]

, 2009
We employed a proteomic profiling strategy to examine the effects of ethanol and betaine diet supplementation on major liver protein level changes. Male Wistar rats were fed control, ethanol or betaine supplemented diets for 4 weeks.
Vigneswara, Vasanthy, Vasanthy Vigneswara, Benita L. McVicker, Tuma, Dean, Carter, Wayne G., Dean Tuma, David E. Ray, McVicker, Benita L., Anna U. Newlaczyl, Newlaczyl, Anna U., Wayne G. Carter, Kharbanda, Kusum K., Kevin Bailey, Ray, David E., Bailey, Kevin, Kusum K. Kharbanda   +15 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Downregulation of Proline Hydroxylase 2 and Upregulation of Hypoxia-Inducible Factor 1α are Associated with Endometrial Cancer Aggressiveness

Cancer Management and Research, 2019
Chengcheng Zhu,1 Huafeng Ding,1 Junwen Yang,1 Yihui Zhou,1 Yonghong Luo,1 Suhua Shi,1 Ying Zhang,1 Yalan Wei,2 Guantai Ni1 1Departments of Gynecology and Obstetrics, Yi Jishan General Hospital of Wannan Medical College, Wuhu, Anhui, People’s ...
Zhu C, Ding H, Yang J, Zhou Y, Luo Y, Shi S, Zhang Y, Wei Y, Ni G   +8 more
doaj  

Perfluorooctanesulfonic acid exposure leads to downregulation of 3-hydroxy-3-methylglutaryl-CoA synthase 2 expression and upregulation of markers associated with intestinal carcinogenesis in mouse intestinal tissues [PDF]

Perfluorooctanesulfonic acid (PFOS) is a widely recognized environment pollutant known for its high bio- accumulation potential and a long elimination half-life.
Durham, Jerika, Goettl, Ryan A., Lee, Eun Y., Wang, Qingding, Zaytseva, Yekaterina Y., Banerjee, Moumita, Hennig, Bernhard, Wang, Chi, He, Daheng, Evers, B. Mark, Li, Chang, Tessmann, Josiane Weber, Deng, Pan   +12 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Saikosaponin D alleviates inflammatory response of osteoarthritis and mediates autophagy via elevating microRNA-199-3p to target transcription Factor-4

Journal of Orthopaedic Surgery and Research
Objective This study was to investigate the underlying mechanism by which Saikosaponin D (SSD) mitigates the inflammatory response associated with osteoarthritis (OA) and regulates autophagy through upregulation of microRNA (miR)-199-3p and ...
Ming Yan, DaWei Zhang, Min Yang
doaj   +1 more source

Supplementary Figures from MCPIP1 Downregulation in Clear Cell Renal Cell Carcinoma Promotes Vascularization and Metastatic Progression

, 2017
Supplementary Figure S1. Downregulation level of MCPIP1 using siRNA or shRNA. Supplementary Figure S2. Effect of MCPIP1 downregulation level on tutor growth. Supplementary Figure S3.
Jolanta Jura (775918), Marcin Majka (14169828), Judyta Górka (14926677), Zofia Mazurek (14926680), Waclaw Wilk (14926683), Paulina Marona (14921763), Katarzyna Miekus (14926686), Janusz Rys (733504)   +7 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source