Results 111 to 120 of about 378,928 (303)

Downregulation of miR-221–3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1

, 2023
Background: Gastric cancer (GC) is an aggressive gastrointestinal tumor. MiRNAs participate in the tumorigenesis of GC. Nevertheless, the function of miR-221–3p in GC remains largely unknown. Methods: RNA levels were assessed by RT-qPCR. Western blot was
Chun-Fang Xu, Hai-Lang Zhou, Chang-Jiang Shao, Xu-Zhu Gao   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

NagPIBAF upregulation and ompO downregulation compromise oxidative stress tolerance of Stenotrophomonas maltophilia

BMC Microbiology
Background Outer membrane protein OmpA is composed of two domains, an N-terminal β-barrel structure embedded in the outer membrane and a C-terminal globular domain noncovalently associated with the peptidoglycan layer in periplasm.
Tsuey-Ching Yang, Shao-Chi Wu, Ting-Yu Yeh, Hsu-Feng Lu, Yi-Tsung Lin, Li-Hua Li   +5 more
doaj   +1 more source

Microrna-135A-5P promotes proliferation and metastasis of hepatocelluar carcinoma cells via down-regulation of FOXO1

Brazilian Journal of Pharmaceutical Sciences
Numerous studies have focused on microRNAs (miRNAs) in hepatocellular carcinoma (HCC). However, the specific role of miR-135a-5p in HCC has remained unclear.
Tian Zhang, Lingling Guan, Xiaomeng Xie, Lixing Guo, Dongjing Ni   +4 more
doaj   +1 more source

Molecular docking investigation of the amantadine binding to the enzymes upregulated or downregulated in Parkinson’s disease [PDF]

ADMET and DMPK, 2020
<p class="ADMETabstracttext">Parkinson’s disease (PD) is a progressive neurodegenerative disease. Levodopa in combination with amantadine has a demonstrated efficacy in motility impairment. An extensive investigation of some enzymes described to be upregulated or downregulated in PD was made – adenylate kinase (AK), adenine ...
openaire   +4 more sources

Supplemental material for Downregulation of glucose-6-phosphate dehydrogenase contributes to diabetic neuropathic pain through upregulation of toll-like receptor 4 in rats

, 2019
Supplemental Material for Downregulation of glucose-6-phosphate dehydrogenase contributes to diabetic neuropathic pain through upregulation of toll-like receptor 4 in rats by Qian Sun, Bing-Yu Zhang, Ping-An Zhang, Ji Hu, Hong-Hong Zhang and Guang-Yin Xu
Bing-Yu Zhang (126454), Hong-Hong Zhang (551345), Qian Sun (53880), Ji Hu (118041), Ping-An Zhang (6643622), Guang-Yin Xu (291460)   +5 more
core   +1 more source

E2F1 Downregulation by Arsenic Trioxide in Lung Adenocarcinoma [PDF]

, 2014
Lung cancer is one of the most common cancers worldwide. Arsenic trioxide (ATO) has been approved by the U.S. Food and Drug Administration for the treatment of acute promyelocytic leukemia.
Lam, SK, Zheng, CY, Leung, LL, Li, YY, Ho, JCM   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1

Annals of Dermatology
Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes ...
Lipeng Tang, Bowen Zhang, Guanzhuo Li, Xinmin Qiu, Zixin Dai, Hongying Liu, Ying Zhu, Bing Feng, Zuqing Su, Wenhui Han, Huilin Huang, Qiuping Li, Zihao Zhang, Maojie Wang, Huazhen Liu, Yuchao Chen, Yanmei Zhang, Dinghong Wu, Xirun Zheng, Taohua Liu, Jie Zhao, Chutian Li, Guangjuan Zheng   +22 more
openaire   +2 more sources

Downregulation of CCL2 induced by the upregulation of microRNA-206 is associated with the severity of HEV71 encephalitis

Molecular Medicine Reports, 2017
MicroRNAs (miRNAs) have been investigated widely as key regulators of gene expression in different diseases by affecting the miRNA‑mediated regulatory function. Human enterovirus 71 (HEV71) can cause a series of human diseases, including encephalitis.
Zhang, Guangyou, Wang, Jiwen, Yao, Guo, Shi, Baohai   +3 more
openaire   +3 more sources