Results 271 to 280 of about 378,928 (303)

Comparative Transcriptomics of PKD1 Downregulation and PKA Upregulation or Downregulation

Journal of the American Society of Nephrology: JASN, 2022
Xiaogang Li, Peter C Harris, Vicente E Torres   +2 more
exaly   +2 more sources

Emotion Downregulation Targets Interoceptive Brain Regions While Emotion Upregulation Targets Other Affective Brain Regions [PDF]

Journal of Neuroscience, 2022
Researchers generally agree that when upregulating and downregulating emotion, control regions in the prefrontal cortex turn up or down activity in affect-generating brain areas.
Julian F Thayer, Shelby L Bachman, Mara Mather   +2 more
exaly   +2 more sources

Application of antimicrobial polypeptide host defenses to aquaculture: Exploitation of downregulation and upregulation responses

Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2011
Antimicrobial polypeptides (AMPPs), consisting of peptides and small proteins with antimicrobial activity, are an integral component of innate immunity. Their often potent properties and widespread prevalence in fish suggests that designing means of manipulating their levels has considerable potential for maintaining or improving fish health.
Anirudh J Ullal, Jorge M O Fernandes, Edward J Noga   +2 more
exaly   +3 more sources

Downregulation of Tsx and OmpW and Upregulation of OmpX Are Required for Iron Homeostasis in Escherichia coli

Journal of Proteome Research, 2008
Upregulation of outer membrane (OM) proteins was systematically investigated in response to poor iron availability in the host and natural environments, but downregulation of OM proteins was ill-defined in this response.
Xuan-Xian Peng, Xiangmin Lin, San-Ying Wang   +2 more
exaly   +2 more sources

Cadmium induced redistribution of cholesterol by upregulating ABCA1 and downregulating OSBP

Journal of Inorganic Biochemistry, 2018
Human exposure to cadmium (Cd) could lead to alterations in lipid metabolism. However, the underlying mechanism is still unclear. In the present study, the data revealed that Cd exposure induced cholesterol redistribution both in vivo from mouse liver tissue into the serum, and in vitro from the HepG2 cells to the cultured medium, which were associated
Yanwei, Wang, Xingqi, Ji, Shuya, Dai, Haitao, Liu, Dandan, Yan, Yang, Zhou, Jie, Gu, Haifeng, Shi   +7 more
openaire   +2 more sources

Rational antigen modification as a strategy to upregulate or downregulate antigen recognition

Current Opinion in Immunology, 2000
Recent and rapid advances in our understanding of the cellular and molecular mechanisms of antigen recognition by CD8(+) and CD4(+) T lymphocytes have led to the birth of possibilities for site-directed, rational modification of cognate antigenic determinants.
S I, Abrams, J, Schlom
openaire   +2 more sources

Identification of genes with universally upregulated or downregulated expressions in colorectal cancer

Journal of Gastroenterology and Hepatology, 2018
AbstractBackground and AimDifferentially expressed (DE) genes detected at the population‐level through case–control comparison provide no information on the dysregulation frequencies of DE genes in a cancer. In this work, we aimed to identify the genes with universally upregulated or downregulated expressions in colorectal cancer (CRC).MethodsWe ...
Kai, Song, Wei, Su, Yanlong, Liu, Jiahui, Zhang, Qirui, Liang, Na, Li, Qingzhou, Guan, Jun, He, Xuefeng, Bai, Wenyuan, Zhao, Zheng, Guo   +10 more
openaire   +2 more sources

Upregulation of renin-angiotensin system and downregulation of kallikrein in obstructive nephropathy

American Journal of Physiology-Renal Physiology, 1993
The purpose of this study was to delineate the effects of prolonged (1 and 5 wk) unilateral ureteral obstruction (UUO) on the intrarenal renin-angiotensin and kallikrein-kinin systems in the rat. Systolic blood pressure (SBP) and plasma angiotensin (ANG) II levels were significantly higher at 1 and 5 wk of obstruction than in sham-operated groups ...
S S, el-Dahr, J, Gee, S, Dipp, B G, Hanss, R C, Vari, J, Chao   +5 more
openaire   +2 more sources

Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma

International Journal of Experimental Pathology, 2022
AbstractHepatocellular carcinoma (HCC) is the most predominant type of liver cancer and is frequently fatal. Alpha‐fetoprotein, alpha‐fetoprotein‐L3, and protein induced by vitamin K absence or antagonist‐II are used as biomarkers to diagnose HCC. However, these biomarkers are not highly specific, especially for early‐stage HCC diagnosis; therefore ...
Sachiko Imanishi, Shoko Nagata, Toshitsugu Fujita, Hodaka Fujii   +3 more
openaire   +2 more sources

Upregulated lncRNA UCA1 inhibits trophoblast cell invasion and proliferation by downregulating JAK2

Journal of Cellular Physiology, 2020
AbstractNumerous studies have suggested that urothelial cancer‐associated 1 (UCA1) acts as a suppressor gene affecting cell proliferation and migration. However, the biological role and the potential mechanism of UCA1 in the progression of pre‐eclampsia (PE) remains unclear.
Jie Liu, Chengyan Luo, Chu Zhang, Qian Cai, Jihui Lin, Tong Zhu, Xiaojie Huang   +6 more
openaire   +2 more sources