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Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis
Proceedings of the National Academy of Sciences of the United States of America, 2016 Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a
Young-Kook Kim, Vic Narry Kim
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Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates
Molecular Cell, 2017 MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions, DROSHA serves as a main determinant of miRNA sequences and a highly selective ...
Vic Narry Kim, Baekgyu Kim, Kyowon Jeong
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Structural Basis for pri-miRNA Recognition by Drosha
Molecular Cell, 2020Hong-Wei Wang, Chao-Pei Liu, Jia Wang
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Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA
Molecular Cell, 2020Byung-Cheon Jeong +2 more
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Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha
EMBO Journal, 2005Rui Yi, Bryan R. Cullen
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Lower and upper stem–single-stranded RNA junctions together determine the Drosha cleavage site
Proceedings of the National Academy of Sciences of the United States of America, 2013Hongming Ma, Haoquan Wu, Yonggan Wu
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