Results 101 to 110 of about 29,512 (257)

Mitochondrial fission regulates germ cell differentiation by suppressing ROS-mediated activation of Epidermal Growth Factor Signaling in the Drosophila larval testis. [PDF]

, 2019
Mitochondria are essential organelles that have recently emerged as hubs for several metabolic and signaling pathways in the cell. Mitochondrial morphology is regulated by constant fusion and fission events to maintain a functional mitochondrial network ...
Jones, D Leanne, Sênos Demarco, Rafael
core   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior

iScience
Summary: Mitochondrial division controls the size, distribution, and turnover of this essential organelle. A dynamin-related GTPase, Drp1, drives membrane division as a force-generating mechano-chemical enzyme.
Arisa Ikeda, Miho Iijima, Hiromi Sesaki
doaj   +1 more source

OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability. [PDF]

, 2012
BackgroundMitochondrial fusion protein mutations are a cause of inherited neuropathies such as Charcot-Marie-Tooth disease and dominant optic atrophy.
Bers, Donald M, Chen, Le, Chiamvimonvat, Nipavan, Cortopassi, Gino, Davies, Vanessa, Knowlton, Anne A, Liu, Tingting, Lu, Xiyuan, Tomilov, Alexey A, Tran, Alice, Votruba, Marcela   +10 more
core   +2 more sources

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Measuring Drp1 Activity in Mitochondrial Fission In Vivo

, 2020
Mitochondrial fission is mainly regulated by a number of dynamin superfamily proteins or DSPs, of which dynamin-like protein 1 (Drp1) is responsible for the scission process during mitochondrial fission. Here we describe several methods, including monitoring mitochondrial distribution, phosphorylation, and tetramer level of Drp1, to examine the ...
Di, Hu, Xin, Qi
openaire   +3 more sources

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons [PDF]

, 2015
Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal early during embryonic development or around ...
A Eckert, A Grimm, A Schmidt, A Sudarov, AI Nesvizhskii, AM Bliek, AY Abramov, B Oettinghaus, B Oettinghaus, C Savoia, C Tian, EC Cheung, G Erdmann, G Twig, G-L McLelland, GF Kelso, GM Cereghetti, GSB Williams, H Chen, H Li, H Otera, H Yuan, HR Waterham, HT Bui, J Bischofberger, J Grohm, J Hench, J M Schulz, J Nunnari, J Wakabayashi, JK Kern, JR Friedman, K Meuer, K Mihara, K Schmitt, KW Young, L M Restelli, L Morè, L Scorrano, M Beck, M Licci, M Tolnay, ME Ragozzino, MJ Barsoum, N Ishihara, N Ishihara, N Mizushima, N Zhang, OM De Brito, P D'Adamo, P Franken, P Verstreken, RK Dagda, S Cipolat, S Frank, S Preibisch, SW Park, T Glatter, T Koshiba, T Uo, V Costa, V Rhein, X Wang, Y Kageyama, YJ Lee, Z-H Sheng   +65 more
core   +2 more sources

Research advances in the applications of mitochondria‐targeted cyanine dyes in imaging

VIEW, EarlyView.
Near‐infrared (NIR) fluorescence imaging, a novel non‐invasive diagnostic tool, plays a crucial role in the imaging and monitoring of solid tumors. At its core are NIR fluorescent dyes, which are widely utilized due to their ability to minimize tissue autofluorescence interference, thereby significantly enhancing the signal‐to‐noise ratio (SNR) and ...
Hongye Liao, Jingyu Deng, Qin Li, Tong Xia, Xun Yang, Simei Yang, Changzhen Sun, Xia Xiong, Li Liu   +8 more
wiley   +1 more source

Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography [PDF]

, 2017
The effects of mitofusin 2 (MFN2) deficiency, on mitochondrial morphology and the mitochondria-junctional sarcoplasmic reticulum (jSR) complex in the adult heart, have been previously investigated using 2D electron microscopy, an approach which is unable
Cabrera-Fuentes, Hector, Chakraborty, Bibhas, Chinda, Kroekkiat, Cooper, Jackie, Dorn, Gerald W, II, Fan, Qiao, Hall, Andrew R, Hausenloy, Derek J, Hernandez-Resendiz, Sauri, Kalkhoran, Siavash Beikoghli, Ong, Sang-Bing, White, Ian J, Yellon, Derek M   +12 more
core   +2 more sources