Results 111 to 120 of about 22,509 (230)

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation [PDF]

Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases.
Singh, Randhwaj Pratap, Olmo González, D., Tishina, Sofya, von Karstedt, Silvia, García-Sáez, A. ; https://orcid.org/, Tishina, S., Olmo González, Daniel, Prieto Clemente, Laura, Yapici, F., Pedrera, Lohans, Lotfipour Nasudivar, S., Dahlhaus, Alina, Langer, T., Langer, Thomas, Pedrera, L., Yapici, Fatma Isil, Grotehans, Nils, Singh, R., Stroh, Jenny, Dahlhaus, A., Lotfipour Nasudivar, Sara, García-Sáez, Ana J., Grotehans, N., Stroh, J., García-Sáez, A., von Karstedt, S., Prieto Clemente, L.   +26 more
core   +2 more sources

Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells

Journal of Orthopaedic Translation
Objective: Dynamin-related protein 1 (Drp1) plays a crucial role in various inflammatory and degenerative diseases, yet its involvement in intervertebral disc degeneration (IVDD) remains poorly understood.
Shenkai Su, Xuanzhang Wu, Bin Li, Fengyu Zhang, Kaiying Zhang, Hui Wang, Yan Lin, Jiaoxiang Chen   +7 more
doaj   +1 more source

Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.
Chrysovalantis Stachteas, Nikolaos Georgogiannis, George G. Nastos, Panagiotis N. Chatzinikolaou, Petros C. Dinas, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Athanasios Z. Jamurtas, Ioannis G. Fatouros, Michalis G. Nikolaidis, Nikos V. Margaritelis   +12 more
wiley   +1 more source

DRP1: a novel regulator of PCSK9 secretion and degradation [PDF]

Cardiovascular Research, 2021
Sean A Burnap, Manuel Mayr
openaire   +3 more sources

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source

The role of mitochondrial fission factor Drp1 in angiogenesis [PDF]

, 2018
Because of the mostly glycolytic nature of endothelial cell metabolism, the role of mitochondria and mitochondrial shape in angiogenesis, the new blood vessel formation from existing vasculature, has not been studied.
Chergova, Maya
core  

Mitochondrial alterations as potential early events in neuromuscular junction remodelling with muscle disuse

Experimental Physiology, EarlyView.
Abstract Physical inactivity impairs neuromuscular health, promoting skeletal muscle atrophy, mitochondrial changes, and neuromuscular junction (NMJ) instability. However, the interplay between mitochondria and NMJ alterations in the context of muscle disuse remains underexplored.
Evgeniia Motanova, Evgenii Lysenko, Fabio Sarto, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Marco V. Narici   +6 more
wiley   +1 more source

Enforced expression of Mfn2 and DRP1 relieves Vpr-induced apoptosis. [PDF]

, 2013
After transient transfection of Mfn2, or DRP1 expression plasmid for 24 hours, cells were infected with Vpr-expressing lentivirus for 72 hours. A, In contrast to Lenti-Vpr negative (-) HEK293 cells (medium control and vector control), the 89 kDa cleavage
Shiow-Her Chiou (329314), Chih-Yang Huang (54970), Kuan-Chih Chow (329315), Shu-Fen Chiang (329312), Tze-Yi Lin (329313)   +4 more
core   +1 more source

Protective Effect of Aerobic Training along with Resveratrol on Mitochondrial Dynamics of Cardiac Myocytes in Animal Model of Non-alcoholic Fatty Liver Disease

Journal of Ardabil University of Medical Sciences, 2019
Background & objectives: Non-alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction. The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of OPA1 and DRP1 in ...
hasan delroz, Ahmad Abdi, Alireza Barari, Parvin Farzanegi   +3 more
doaj  

ISGylation of DRP1 closely balances other post-translational modifications to mediate mitochondrial fission

Cell Death and Disease
Dynamin related protein 1 (DRP1), a pivotal mitochondrial fission protein, is post-translationally modified by multiple mechanisms. Here we identify a new post-translational modification of DRP1 by the ubiquitin-like protein, interferon-stimulated gene ...
Palamou Das, Oishee Chakrabarti
doaj   +1 more source