Results 131 to 140 of about 22,509 (230)
The Journal of Physiology, EarlyView.Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa +10 more
wiley +1 more source
Cardiovascular DiabetologyDynamin-related protein 1 (Drp1) is a crucial regulator of mitochondrial dynamics, the overactivation of which can lead to cardiovascular disease. Multiple distinct posttranscriptional modifications of Drp1 have been reported, among which S-nitrosylation
Yuqiong Chen +14 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Dose‐dependent effects of radiation on cardiac electrophysiology and arrhythmia susceptibility. At low radiation doses (left), increased reactive oxygen species (ROS) initiate an ROS–Ca2+ positive feedback loop involving calcium/calmodulin‐dependent protein kinase II (CaMKII) activation, enhanced L‐type Ca2+ current (ICaL ...
Hannah M. Zukowski, Colleen E. Clancy
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald +5 more
wiley +1 more source
SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia
The Journal of Physiology, EarlyView.Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu +5 more
wiley +1 more source
The role of Drp1 in adult skeletal muscle physiology [PDF]
The Journal of Physiology, 2020 Valentin Dablainville +1 more
openaire +2 more sources
Mechanistic insights into metabolic function of dynamin-related protein 1
Journal of Lipid ResearchDynamin-related protein 1 (DRP1) plays crucial roles in mitochondrial and peroxisome fission. However, the mechanisms underlying the functional regulation of DRP1 in adipose tissue during obesity remain unclear.
Xin Li +12 more
doaj +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Discovery of PHB1 as a Novel Candidate Gene in Dominant Optic Atrophy
Clinical Genetics, Volume 110, Issue 2, Page 165-171, August 2026.A heterozygous PHB1 missense variant (p.Ser147Phe) segregates with autosomal dominant optic atrophy in a multi‐generation family. Structural and cellular analyses suggest altered mitochondrial dynamics, identifying PHB1 as a novel candidate gene for hereditary optic neuropathy. ABSTRACT Hereditary optic neuropathies comprise a genetically heterogeneous
Marija Volk +13 more
wiley +1 more source